Skeletal muscle contractile protein function is preserved in human heart failure.
Skeletal muscle contractile protein function is preserved in human heart failure.
复制标题
骨骼肌收缩蛋白功能在人类心力衰竭中得以保留。
DOI：
10.1152/japplphysiol.01072.2007
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Vanburen,Peter
中科院分区：
文献类型：
--
作者：
Okada,Yoko;Toth,MichaelJ;Vanburen,Peter
Skeletal muscle weakness is a common finding in patients with chronic heart failure (CHF). This functional deficit cannot be accounted for by muscle atrophy alone, suggesting that the syndrome of heart failure induces a myopathy in the skeletal musculature. To determine whether decrements in muscle performance are related to alterations in contractile protein function, biopsies were obtained from the vastus lateralis muscle of four CHF patients and four control patients. CHF patients exhibited reduced peak aerobic capacity and knee extensor muscle strength. Decrements in whole muscle strength persisted after statistical control for muscle size. Thin filaments and myosin were isolated from biopsies and mechanically assessed using the in vitro motility assay. Isolated skeletal muscle thin-filament function, however, did not differ between CHF patients and controls with respect to unloaded shortening velocity, calcium sensitivity, or maximal force. Similarly, no difference in maximal force or unloaded shortening velocity of isolated myosin was observed between CHF patients and controls. From these results, we conclude that skeletal contractile protein function is unaltered in CHF patients. Other factors, such as a decrease in total muscle myosin content, are likely contributors to the skeletal muscle strength deficit of heart failure.
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影响因子：
5.5
作者：
Bottinelli, R;Canepari, M;Reggiani, C
通讯作者：
Reggiani, C
影响因子：
5.5
作者：
D'Antona, G;Pellegrino, MA;Bottinelli, R
通讯作者：
Bottinelli, R
心力衰竭中的骨骼肌肌原纤维蛋白代谢：与免疫激活和功能能力的关系。
DOI：
10.1152/ajpendo.00444.2004
发表时间：
2005
期刊：
American journal of physiology. Endocrinology and metabolism
影响因子：
--
作者：
Toth,MichaelJ;Matthews,DwightE;Ades,PhilpA;Tischler,MarcD;VanBuren,Peter;Previs,Michael;LeWinter,MartinM
通讯作者：
LeWinter,MartinM
影响因子：
2.4
作者：
Jung, Hoe-Yune;Lee, An-Na;Kim, Jong-Bae
通讯作者：
Kim, Jong-Bae
影响因子：
3.5
作者：
Toth, Michael J.;Ades, Philip A.;LeWinter, Martin M.
通讯作者：
LeWinter, Martin M.