A new approach to assessing affect and the emotional implications of personal genomic testing for common disease risk.
A new approach to assessing affect and the emotional implications of personal genomic testing for common disease risk.
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DOI：
10.1159/000370101
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发表时间：
2015
影响因子：
1.7
通讯作者：
McBride CM
中科院分区：
文献类型：
--
作者：
O'Neill SC;Tercyak KP;Baytop C;Hensley Alford S;McBride CM
针对常见疾病风险的个人基因组检测（PGT）越来越频繁，但人们对了解其基因组风险概况的一系列情绪反应以及PGT的心理危害/益处知之甚少。我们对PGT后的影响进行了研究，包括测试后可能出现的积极，中性和消极状态。228名健康成年人接受了常见疾病变异的PGT，并在披露后两周内完成了半结构化的研究访谈。研究参与者用自己的话报告了PGT结果给他们带来的感受。使用迭代编码过程，响应被组织成三个广泛的情感类别（消极，中性和积极的影响）。中性情感是最普遍的反应（53.9%），其次是积极情感（26.9%）和消极情感（19.2%）。我们没有发现性别、种族或教育方面的差异。虽然<20%的参与者报告了对学习他们常见疾病基因组风险特征的负面影响，但大多数人经历了中性或积极的情绪。这些发现有助于越来越多的证据表明PGT不会造成重大的心理伤害。此外，他们指出，需要更好地将情感和认知过程中的理论和评估联系起来，以利用PGT信息来改变健康的行为。
Personal genomic testing (PGT) for common disease risk is becoming increasingly frequent, but little is known about people's array of emotional reactions to learning their genomic risk profiles and the psychological harms/benefits of PGT. We conducted a study of post-PGT affect, including positive, neutral, and negative states that may arise after testing. Two hundred twenty-eight healthy adults received PGT for common disease variants and completed a semi-structured research interview within two weeks of disclosure. Study participants reported how PGT results made them feel in their own words. Using an iterative coding process, responses were organized into three broad affective categories (Negative, Neutral, and Positive affect). Neutral affect was the most prevalent response (53.9%), followed by Positive affect (26.9%) and Negative affect (19.2%). We found no differences by gender, race or education. While <20% of participants reported negative affect in response to learning their genomic risk profile for common disease, a majority experience either neutral or positive emotions. These findings contribute to the growing evidence that PGT does not impose significant psychological harms. Moreover, they point to a need to better link theories and assessments in both emotional and cognitive processing to capitalize on PGT information for healthy behavior change.
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DOI：
10.1038/gim.2013.73
发表时间：
2013-07
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.3
作者：
Conner, Mark;Rhodes, Ryan E.;Lawton, Rebecca
通讯作者：
Lawton, Rebecca
影响因子：
3.6
作者：
Esplen, Mary Jane;Stuckless, Noreen;Irwin, Ellen
通讯作者：
Irwin, Ellen
DOI：
10.1038/gim.2013.113
发表时间：
2013-11
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.8
作者：
Anderson, Roger T.;Wenzel, Lari;Adams, Paul
通讯作者：
Adams, Paul