Prenatal and Postnatal Choline Supplementation in Fetal Alcohol Spectrum Disorder.
Prenatal and Postnatal Choline Supplementation in Fetal Alcohol Spectrum Disorder.
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DOI：
10.3390/nu14030688
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发表时间：
2022-02-06
期刊：
影响因子：
5.9
通讯作者：
Wozniak JR
中科院分区：
文献类型：
--
作者：
Ernst AM;Gimbel BA;de Water E;Eckerle JK;Radke JP;Georgieff MK;Wozniak JR
胎儿酒精谱系障碍（FASD）是常见的，代表了一个重大的公共卫生负担，但很少有干预措施已在FASD测试。认知缺陷是FASD的核心特征，范围从广泛的智力障碍到注意力、执行功能、记忆、视觉感知/运动技能、社会认知和学术方面的选择性问题。与FASD相关的认知障碍的一种潜在干预是必需营养素胆碱，已知其在典型和非典型发育中对大脑和认知具有许多直接影响。我们提供了一个文献的总结，支持使用胆碱作为神经发育干预受产前酒精。我们首先讨论酒精如何干扰正常的大脑发育。然后，我们提供了一个全面的概述，营养胆碱，并讨论其在典型的大脑发育中的作用，其应用在优化大脑发育后的早期损伤。接下来，我们回顾了临床前文献，这些文献提供了胆碱作为酒精暴露后干预的潜力的证据。然后，我们回顾了少数现有的人类研究胆碱补充FASD。最后，我们总结了胆碱补充剂的实际考虑，包括剂量，配方和儿童的可行性。
Fetal alcohol spectrum disorder (FASD) is common and represents a significant public health burden, yet very few interventions have been tested in FASD. Cognitive deficits are core features of FASD, ranging from broad intellectual impairment to selective problems in attention, executive functioning, memory, visual–perceptual/motor skills, social cognition, and academics. One potential intervention for the cognitive impairments associated with FASD is the essential nutrient choline, which is known to have numerous direct effects on brain and cognition in both typical and atypical development. We provide a summary of the literature supporting the use of choline as a neurodevelopmental intervention in those affected by prenatal alcohol. We first discuss how alcohol interferes with normal brain development. We then provide a comprehensive overview of the nutrient choline and discuss its role in typical brain development and its application in the optimization of brain development following early insult. Next, we review the preclinical literature that provides evidence of choline’s potential as an intervention following alcohol exposure. Then, we review a handful of existing human studies of choline supplementation in FASD. Lastly, we conclude with a review of practical considerations in choline supplementation, including dose, formulation, and feasibility in children.
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影响因子：
7.1
作者：
Cheatham, Carol L.;Goldman, Barbara Davis;Zeisel, Steven H.
通讯作者：
Zeisel, Steven H.
影响因子：
1.7
作者：
Boseck, Justin J.;Davis, Andrew S.;Gelder, Barbara C.
通讯作者：
Gelder, Barbara C.
影响因子：
3.2
作者：
Brunst, Kelly J.;Wright, Robert O.;DiGioia, Kimberly;Enlow, Michelle Bosquet;Fernandez, Harriet;Wright, Rosalind J.;Kannan, Srimathi
通讯作者：
Kannan, Srimathi
DOI：
10.1111/acer.12082
发表时间：
2013-07
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Bekdash RA;Zhang C;Sarkar DK
通讯作者：
Sarkar DK
影响因子：
2
作者：
Cheng, Ruey-Kuang;MacDonald, Christopher J.;Meck, Warren H.
通讯作者：
Meck, Warren H.