The Hippo pathway regulates hematopoiesis in Drosophila melanogaster.
The Hippo pathway regulates hematopoiesis in Drosophila melanogaster.
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DOI：
10.1016/j.cub.2014.10.031
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发表时间：
2014-11-17
期刊：
影响因子：
9.2
通讯作者：
Harvey, Kieran F.
中科院分区：
文献类型：
--
作者：
Milton, Claire C.;Grusche, Felix A.;Degoutin, Joffrey L.;Yu, Eefang;Dai, Qi;Lai, Eric C.;Harvey, Kieran F.
Salvador-Warts-Hippo（Hippo）通路是器官生长和细胞命运的进化保守调节因子。它在昆虫和哺乳动物的上皮和神经组织以及哺乳动物的器官如肝脏和心脏中执行这些功能。尽管Hippo通路研究进展迅速，但该通路在造血中的决定性作用仍然是个谜。黑腹果蝇和哺乳动物的造血区室具有几个保守的特征。D.黑腹菌拥有三种类型的造血细胞，与哺乳动物的骨髓细胞最相似：浆细胞（巨噬细胞样细胞）、晶细胞（参与伤口愈合）和片细胞（包裹寄生虫）。控制这些细胞分化的蛋白质也控制着哺乳动物重要的血统决定。在这里，我们通过显示Hippo通路控制两种主要类型的D细胞的分化和增殖，将其定义为造血的关键介质。黑腹血细胞、浆细胞和晶细胞。在缺乏下游Hippo途径激酶Warts的动物中，淋巴腺细胞过度增殖，过早分化，并且通常采用混合谱系命运。Hippo通路通过细胞自主和非细胞自主机制调节晶体细胞数量。Yorkie及其伴侣转录因子Scalloped被发现调节Runx家族转录因子Lozenge的转录，Lozenge是晶体细胞命运的关键调节因子。此外，Yorkie或扇贝超活化诱导异位晶体细胞在非细胞自主，和Notch途径依赖的方式。
The Salvador-Warts-Hippo (Hippo) pathway is an evolutionarily conserved regulator of organ growth and cell fate. It performs these functions in epithelial and neural tissues of both insects and mammals, and in mammalian organs such as the liver and heart. Despite rapid advances in Hippo pathway research, a definitive role for this pathway in hematopoiesis has remained enigmatic. The hematopoietic compartments of Drosophila melanogaster and mammals possess several conserved features. D. melanogaster possess three types of hematopoietic cells that most closely resemble mammalian myeloid cells: plasmatocytes (macrophage-like cells), crystal cells (involved in wound healing) and lamellocytes (which encapsulate parasites). The proteins that control differentiation of these cells also control important blood lineage decisions in mammals. Here, we define the Hippo pathway as a key mediator of hematopoiesis by showing that it controls differentiation and proliferation of the two major types of D. melanogaster blood cells, plasmatocytes and crystal cells. In animals lacking the downstream Hippo pathway kinase Warts, lymph gland cells overproliferated, differentiated prematurely and often adopted a mixed lineage fate. The Hippo pathway regulated crystal cell numbers by both cell autonomous and non-cell autonomous mechanisms. Yorkie and its partner transcription factor Scalloped were found to regulate transcription of the Runx family transcription factor, Lozenge, which is a key regulator of crystal cell fate. Further, Yorkie or Scalloped hyperactivation induced ectopic crystal cells in a non-cell autonomous, and Notch pathway-dependent fashion.
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影响因子：
4.6
作者：
Bataillé, L;Augé, B;Waltzer, L
通讯作者：
Waltzer, L
影响因子：
4
作者：
Huang, Hui;Cantor, Alan B.
通讯作者：
Cantor, Alan B.
DOI：
10.1073/pnas.1635050100
发表时间：
2003-09-30
影响因子：
11.1
作者：
Fossett, N;Hyman, K;Schulz, RA
通讯作者：
Schulz, RA
影响因子：
9.2
作者：
Duvic, B;Hoffmann, JA;Royet, J
通讯作者：
Royet, J
影响因子：
9.2
作者：
Goulev, Youlian;Fauny, Jean Daniel;Zider, Alain
通讯作者：
Zider, Alain