Trehalose and trehalose-based polymers for environmentally benign, biocompatible and bioactive materials.
Trehalose and trehalose-based polymers for environmentally benign, biocompatible and bioactive materials.
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DOI：
10.3390/molecules13081773
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发表时间：
2008-08-21
期刊：
影响因子：
--
通讯作者：
Shibata M
中科院分区：
文献类型：
--
作者：
Teramoto N;Sachinvala ND;Shibata M
海藻糖是一种非还原性二糖，存在于许多生物体中，但不存在于哺乳动物中。这种糖在卷柏苔藓、水熊虫（水熊虫）和其他动物的隐生作用中起着重要作用，这些动物从干燥引起的假死状态中复苏。海藻糖的有趣性质是由于其独特的对称低能结构，其中两个葡萄糖单元通过1→1-葡萄糖苷键面对面键合。林原株式会社，由于开发了一种廉价、环境友好的工业规模工艺，用于将α-1，4-连接的聚己糖酶促转化为α，α-d-海藻糖，这使得很容易探索海藻糖及其衍生物的新食品、工业和医药用途。海藻糖化学是一个相对较新的新兴领域，海藻糖衍生物的聚合物显示出环境友好，生物相容性和生物降解性。海藻糖的区别性归因于其结构、对称性、溶解性、动力学和热力学稳定性以及多功能性。虽然基于海藻糖的聚合物网络的合成可以是直接的，但是使用基于海藻糖的单体合成和表征具有定制性质的明确定义的线性聚合物是具有挑战性的，并且通常涉及羟基的保护和脱保护以在所得产物中获得所需的结构、形态、生物学以及物理和化学性质。在这篇综述中，我们将概述已知的文献海藻糖的迷人的参与在隐生物学;突出其在许多领域的应用;然后讨论我们用来制备新的海藻糖为基础的单体和聚合物的方法，并解释它们的性能。
Trehalose is a non-reducing disaccharide that is found in many organisms but not in mammals. This sugar plays important roles in cryptobiosis of selaginella mosses, tardigrades (water bears), and other animals which revive with water from a state of suspended animation induced by desiccation. The interesting properties of trehalose are due to its unique symmetrical low-energy structure, wherein two glucose units are bonded face-to-face by 1→1-glucoside links. The Hayashibara Co. Ltd., is credited for developing an inexpensive, environmentally benign and industrial-scale process for the enzymatic conversion of α-1,4-linked polyhexoses to α,α-d-trehalose, which made it easy to explore novel food, industrial, and medicinal uses for trehalose and its derivatives. Trehalose-chemistry is a relatively new and emerging field, and polymers of trehalose derivatives appear environmentally benign, biocompatible, and biodegradable. The discriminating properties of trehalose are attributed to its structure, symmetry, solubility, kinetic and thermodynamic stability and versatility. While syntheses of trehalose-based polymer networks can be straightforward, syntheses and characterization of well defined linear polymers with tailored properties using trehalose-based monomers is challenging, and typically involves protection and deprotection of hydroxyl groups to attain desired structural, morphological, biological, and physical and chemical properties in the resulting products. In this review, we will overview known literature on trehalose’s fascinating involvement in cryptobiology; highlight its applications in many fields; and then discuss methods we used to prepare new trehalose-based monomers and polymers and explain their properties.
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影响因子：
4
作者：
Behm, CA
通讯作者：
Behm, CA
影响因子：
2.9
作者：
ARAKAWA, T;TIMASHEFF, SN
通讯作者：
TIMASHEFF, SN
DOI：
10.1073/pnas.69.9.2373
发表时间：
1972-01-01
影响因子：
11.1
作者：
BRADBURY, SL;JAKOBY, WB
通讯作者：
JAKOBY, WB
影响因子：
4.4
作者：
Branca, C;Maccarrone, S;Taylor, J
通讯作者：
Taylor, J
DOI：
10.1111/j.1439-0450.2006.00968.x
发表时间：
2006-09-01
期刊：
JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH
影响因子：
--
作者：
Beutin, L.
通讯作者：
Beutin, L.