Morphological abnormalities of the thalamus in youths with attention deficit hyperactivity disorder.
Morphological abnormalities of the thalamus in youths with attention deficit hyperactivity disorder.
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DOI：
10.1176/appi.ajp.2009.09030398
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Peterson BS
中科院分区：
文献类型：
--
作者：
Ivanov I;Bansal R;Hao X;Zhu H;Kellendonk C;Miller L;Sanchez-Pena J;Miller AM;Chakravarty MM;Klahr K;Durkin K;Greenhill LL;Peterson BS
丘脑在注意缺陷多动障碍（ADHD）发生中的作用仍然知之甚少。作者使用解剖MRI检查了患有ADHD的青少年和健康对照青少年的丘脑形态。作者在一项横断面病例对照研究中检查了46名患有ADHD的青少年和59名8-18岁的对照青少年。常规体积和丘脑表面形态的测量作为主要的结果测量。比较整个丘脑体积的混合效应模型显示组间无显著差异。地图的丘脑表面显示显着较小的区域体积双边枕在青少年多动症相对于比较科目。事后分析显示，接受兴奋剂的ADHD患者（N=31）比未经治疗的ADHD青少年具有更大的常规丘脑体积，并且丘脑表面的地图显示接受兴奋剂的患者的枕扩大。右外侧和左后丘脑表面较小的区域体积与更严重的多动症状相关，而右内侧丘脑表面较大的区域体积与更严重的注意力不集中症状相关。这些发现表明ADHD青少年的枕体积减少，并表明与未经治疗的患者相比，接受兴奋剂治疗的患者的枕体积相对增大。多动分数与外侧丘脑表面上较小的区域体积和注意力不集中分数与内侧丘脑表面上较大的区域体积的关联表明丘脑子回路在不同ADHD症状的发病机制中的差异参与。
The role of the thalamus in the genesis of attention deficit hyperactivity disorder (ADHD) remains poorly understood. The authors used anatomical MRI to examine the morphology of the thalamus in youths with ADHD and healthy comparison youths. The authors examined 46 youths with ADHD and 59 comparison youths 8–18 years of age in a cross-sectional case-control study. Conventional volumes and measures of surface morphology of the thalamus served as the main outcome measures. A mixed-effects model comparing whole thalamic volumes revealed no significant differences between groups. Maps of the thalamic surface revealed significantly smaller regional volumes bilaterally in the pulvinar in youths with ADHD relative to comparison subjects. Post hoc analyses showed that ADHD patients who received stimulants (N=31) had larger conventional thalamic volumes than untreated youths with ADHD, and maps of the thalamic surface showed enlargement over the pulvinar in those receiving stimulants. Smaller regional volumes in the right lateral and left posterior thalamic surfaces were associated with more severe hyperactivity symptoms, whereas larger regional volumes in the right medial thalamic surfaces were associated with more severe symptoms of inattention. These findings demonstrate reduced pulvinar volumes in youths with ADHD and indicate that this same area is relatively enlarged in patients treated with stimulants compared to those untreated. Associations of hyperactivity scores with smaller regional volumes on the lateral thalamic surface and inattention scores with larger regional volumes on the medial thalamic surface suggest the differential involvement of thalamic subcircuits in the pathogenesis of differing ADHD symptoms.
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影响因子：
10.6
作者：
Bansal, Ravi;Staib, Lawrence H.;Peterson, Bradley S.
通讯作者：
Peterson, Bradley S.
DOI：
10.1111/j.1469-7610.2006.01671.x
发表时间：
2006-10-01
影响因子：
7.6
作者：
Dickstein, Steven G.;Bannon, Katie;Milham, Michael P.
通讯作者：
Milham, Michael P.
DOI：
10.1111/j.1749-6632.2003.tb07094.x
发表时间：
2003-01-01
期刊：
AMYGDALA IN BRAIN FUNCTION: BASIC AND CLINICAL APPROACHES
影响因子：
--
作者：
Bechara, A;Damasio, H;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
17.7
作者：
Frazier, JA;Chiu, SF;Biederman, J
通讯作者：
Biederman, J
影响因子：
5.7
作者：
Das, P;Kemp, AH;Williams, LM
通讯作者：
Williams, LM