CircRNAs: novel therapeutic targets in multiple myeloma
CircRNAs: novel therapeutic targets in multiple myeloma
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CircRNA：多发性骨髓瘤的新治疗靶点
DOI：
10.1007/s11033-022-07668-8
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Juan Du
中科院分区：
文献类型：
--
作者：
Xinyi Zhou;Juan Du
研究背景环状RNA（Circular RNA）是近年来引起研究者关注的一类非编码RNA。多发性骨髓瘤（MM）是一种预后不良的血液恶性肿瘤，这表明迫切需要更好的治疗方案，特别是在生物学指标方面。根据最近的研究发现，circRNA的存在也与恶性血液病的发生和进展密切相关。本文就circRNA在MM中的生物学特性和功能以及circRNA在MM的诊断、预后和治疗中的临床应用进行综述。结论circRNA参与基因转录、翻译和表观遗传修饰以及对癌细胞增殖、侵袭和转移的调节，因此，circRNA有望成为未来MM的潜在生物标志物。图形摘要
BackgroundCircular RNA (circRNA) is a type of non-coding RNA that has recently attracted the attention of researchers. Multiple myeloma (MM) is a hematological malignancy with a dismal prognosis that indicates a pressing need for better treatment alternatives, particularly in terms of biological indicators. According to recent research findings, the presence of circRNA is also closely related to the incidence and progression of malignant hemopathy. There have been, however, only a few investigations of circRNA in MM.Material and methodsThis review will be on the biological properties and functions of circRNA in MM and a discussion of the clinical utility of circRNA in the diagnosis, prognosis, and treatment of MM.ConclusionsCircRNA is involved in gene transcription, translation, and epigenetic modification as well as the regulation of cancer cell proliferation, invasion, and metastasis, and hence, promotes or inhibits the occurrence and progression of MM. Therefore, circRNA holds promise as a potential future MM biomarker.Graphical abstract
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