MicroRNAs as diagnostic markers and therapeutic targets for traumatic brain injury.
MicroRNAs as diagnostic markers and therapeutic targets for traumatic brain injury.
复制标题
DOI：
10.4103/1673-5374.219025
复制
发表时间：
2017-11
影响因子：
6.1
通讯作者：
Peplow PV
中科院分区：
文献类型：
--
作者：
Martinez B;Peplow PV
创伤性脑损伤（Traumatic brain injury，TBI）的特征在于来自外部机械力的对脑的原发性损伤以及由于最终导致神经元细胞死亡的各种分子和病理生理学反应而导致的继发性损伤。继发性脑损伤事件可能在创伤后数分钟、数小时甚至数天发生，并提供有价值的治疗靶点以防止进一步的神经元变性。目前，TBI还没有有效的治疗方法，部分原因是在初始损伤后的不同时间点发生的许多复杂的继发性生物化学和病理生理学事件的广泛影响。microRNA控制着一系列生理和病理功能，如发育、分化、凋亡和代谢，并可作为TBI进展评估和干预的潜在靶点，以减轻对脑的继发性损伤。这对提高脑损伤的诊断准确性和长期结果以及潜在的新治疗方法具有重要意义。最近的人类研究已经确定血清/血浆中的特定microRNA（miR-425-p、-21、-93、-191和-499）和脑脊液（CSF）中的特定microRNA（miR-328、-362-3p、-451、-486a）作为TBI的诊断、严重程度和预后的可能指标。实验动物研究已经检查了作为中度和轻度TBI的生物标志物和治疗靶点的特定microRNA（例如，miR-21、miR-23b）。自愿运动改变了microRNA谱。成年和老年动物脑中基础microRNA表达的差异以及对TBI反应的改变（例如，miR-21）也有报道。需要对TBI患者进行进一步的大规模研究，以提供更多关于不同年龄组（儿童，成人和老年人）microRNA谱变化的信息。
Traumatic brain injury (TBI) is characterized by primary damage to the brain from the external mechanical force and by subsequent secondary injury due to various molecular and pathophysiological responses that eventually lead to neuronal cell death. Secondary brain injury events may occur minutes, hours, or even days after the trauma, and provide valuable therapeutic targets to prevent further neuronal degeneration. At the present time, there is no effective treatment for TBI due, in part, to the widespread impact of numerous complex secondary biochemical and pathophysiological events occurring at different time points following the initial injury. MicroRNAs control a range of physiological and pathological functions such as development, differentiation, apoptosis and metabolism, and may serve as potential targets for progress assessment and intervention against TBI to mitigate secondary damage to the brain. This has implications regarding improving the diagnostic accuracy of brain impairment and long-term outcomes as well as potential novel treatments. Recent human studies have identified specific microRNAs in serum/plasma (miR-425-p, -21, -93, -191 and -499) and cerebro-spinal fluid (CSF) (miR-328, -362-3p, -451, -486a) as possible indicators of the diagnosis, severity, and prognosis of TBI. Experimental animal studies have examined specific microRNAs as biomarkers and therapeutic targets for moderate and mild TBI (e.g., miR-21, miR-23b). MicroRNA profiling was altered by voluntary exercise. Differences in basal microRNA expression in the brain of adult and aged animals and alterations in response to TBI (e.g., miR-21) have also been reported. Further large-scale studies with TBI patients are needed to provide more information on the changes in microRNA profiles in different age groups (children, adults, and elderly).
登录
查看更多内容
影响因子：
4.6
作者：
Bhomia M;Balakathiresan NS;Wang KK;Papa L;Maheshwari RK
通讯作者：
Maheshwari RK
影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
4.2
作者：
Davis, Laurie M.;Pauly, James R.;Sullivan, Patrick G.
通讯作者：
Sullivan, Patrick G.
影响因子：
1.9
作者：
Chandran, Raghavendar;Sharma, Anuj;Maheshwari, Radha K.
通讯作者：
Maheshwari, Radha K.