Nerve maintenance and regeneration in the damaged cochlea.
Nerve maintenance and regeneration in the damaged cochlea.
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DOI：
10.1016/j.heares.2011.04.019
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发表时间：
2011-11
期刊：
影响因子：
2.8
通讯作者：
Raphael, Yehoash
中科院分区：
文献类型：
--
作者：
Shibata, Seiji B.;Budenz, Cameron L.;Bowling, Sara A.;Pfingst, Bryan E.;Raphael, Yehoash
感音神经性听力损失发生后，人和动物的机械敏感毛细胞和螺旋神经节细胞（SGC）会不同程度地发生退化，并且神经退化程度越高，耳聋持续时间越长。人工耳蜗的出现为许多听力障碍患者提供了急需的帮助，并已成为全世界公认的治疗方法。然而，持续的周围神经纤维退化和随后的 SGC 体退化会减少人工耳蜗刺激的神经靶点并削弱其功能。人们对旨在通过防止 SGC 体变性和/或将周围神经纤维再生为聋人感觉上皮来增强人工耳蜗功效的生物工程方法越来越感兴趣。我们回顾了受损动物耳蜗神经维持和再生方面的进展，重点是损伤后输送到内耳的神经营养因子的治疗能力。此外，我们总结了内耳神经元变性的组织学过程，并描述了用于研究该机制的不同动物模型。研究增强聋耳蜗的生物基础设施以提高人工耳蜗的功效具有直接的临床意义。
Following the onset of sensorineural hearing loss, degeneration of mechanosensitive hair cells and spiral ganglion cells (SGCs) in humans and animals occurs to variable degrees, with a trend for greater neural degeneration with greater duration of deafness. Emergence of the cochlear implant prosthesis has provided much needed aid to many hearing impaired patients and has become a well-recognized therapy worldwide. However, ongoing peripheral nerve fiber regression and subsequent degeneration of SGC bodies can reduce the neural targets of cochlear implant stimulation and diminish its function. There is increasing interest in bio-engineering approaches that aim to enhance cochlear implant efficacy by preventing SGC body degeneration and/or regenerating peripheral nerve fibers into the deaf sensory epithelium. We review the advancements inmaintaining and regeneratingnerves indamaged animal cochleae, with an emphasis on the therapeutic capacity of neurotrophic factorsdelivered to the inner ear after an insult. Additionally, we summarize the histological process of neuronal degeneration in the inner ear and describe different animal models that have been employed to study this mechanism. Research on enhancing the biological infrastructure of the deafened cochlea in order to improve cochlear implant efficacy is of immediate clinical importance.
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影响因子：
2.8
作者：
Cohen, LT;Saunders, E;Cowan, RSC
通讯作者：
Cowan, RSC
DOI：
10.1007/s10162-010-0234-3
发表时间：
2010-12-01
影响因子：
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作者：
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作者：
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通讯作者：
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1.4
作者：
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影响因子：
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作者：
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通讯作者：
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