Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity.
Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity.
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DOI：
10.3390/ijms18071456
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发表时间：
2017-07-06
影响因子：
5.6
通讯作者：
Moltó MD
中科院分区：
文献类型：
--
作者：
Calap-Quintana P;González-Fernández J;Sebastiá-Ortega N;Llorens JV;Moltó MD
铁、铜和锌是生命所必需的过渡金属，因为它们是许多生物过程所必需的。生物体已经进化到从营养中获取金属，并保持每种金属的足够水平，以避免与其不足、过剩或错位相关的破坏性影响。有趣的是，金属动态平衡通路的主要组成部分是保守的，许多人类金属相关基因的同源基因已经在果蝇中被鉴定和表征。果蝇被认为是研究人类疾病的有用模型，包括那些由控制细胞金属动态平衡的途径突变引起的疾病。苍蝇在实验室中具有许多优势，如生命周期短、易于操作和维护费用低廉。此外，它们还可以大量饲养。此外，苍蝇非常受欢迎，因为它们提供了相当多的遗传工具来解决一些关于疾病病理的悬而未决的问题，这反过来又有助于我们对金属代谢和动态平衡的理解。本文综述了主要过渡金属铁、锌和铜在果蝇体内的代谢，以及该生物作为一种实验模型在探索金属代谢失调在不同人类疾病中的作用。最后，总结了果蝇作为检测金属毒性模型的贡献。
Iron, copper and zinc are transition metals essential for life because they are required in a multitude of biological processes. Organisms have evolved to acquire metals from nutrition and to maintain adequate levels of each metal to avoid damaging effects associated with its deficiency, excess or misplacement. Interestingly, the main components of metal homeostatic pathways are conserved, with many orthologues of the human metal-related genes having been identified and characterized in Drosophila melanogaster. Drosophila has gained appreciation as a useful model for studying human diseases, including those caused by mutations in pathways controlling cellular metal homeostasis. Flies have many advantages in the laboratory, such as a short life cycle, easy handling and inexpensive maintenance. Furthermore, they can be raised in a large number. In addition, flies are greatly appreciated because they offer a considerable number of genetic tools to address some of the unresolved questions concerning disease pathology, which in turn could contribute to our understanding of the metal metabolism and homeostasis. This review recapitulates the metabolism of the principal transition metals, namely iron, zinc and copper, in Drosophila and the utility of this organism as an experimental model to explore the role of metal dyshomeostasis in different human diseases. Finally, a summary of the contribution of Drosophila as a model for testing metal toxicity is provided.
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影响因子：
3.5
作者：
Anderson, PR;Kirby, K;Phillips, JP
通讯作者：
Phillips, JP
影响因子：
4.4
作者：
Bianchini, Matheus Chimelo;Alves Gularte, Claudia Ortiz;Puntel, Robson L.
通讯作者：
Puntel, Robson L.
影响因子：
2.8
作者：
Bettedi, Lucia;Aslam, Mohamad F.;Missirlis, Fanis
通讯作者：
Missirlis, Fanis
影响因子：
3.5
作者：
Bonilla-Ramirez, Leonardo;Jimenez-Del-Rio, Marlene;Velez-Pardo, Carlos
通讯作者：
Velez-Pardo, Carlos
DOI：
10.1258/ebm.2010.009258
发表时间：
2010-06
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Bozym RA;Chimienti F;Giblin LJ;Gross GW;Korichneva I;Li Y;Libert S;Maret W;Parviz M;Frederickson CJ;Thompson RB
通讯作者：
Thompson RB