Separability of neural responses to standardised mechanical stimulation of limbs.
Separability of neural responses to standardised mechanical stimulation of limbs.
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DOI：
10.1038/s41598-017-11349-z
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发表时间：
2017-09-11
影响因子：
4.6
通讯作者：
Nazarpour K
中科院分区：
文献类型：
--
作者：
Brunton E;Blau CW;Nazarpour K
目前正在为开发神经假体作出相当大的科学和技术努力。了解周围神经系统如何对肢体的机电刺激做出反应，将有助于设计可以恢复功能或加速感觉运动系统损伤恢复的假肢。然而，由于实验方案的差异，很难（如果不是不可能）在不同的周围神经接口之间进行有意义的比较。因此，我们开发了一个低成本的电子系统来模拟大鼠后爪的机械刺激。三种类型的机械刺激，即本体感觉，触摸和伤害性刺激被传递到肢体和神经电图信号同时记录从坐骨神经与16触点袖口电极。这是第一次，结果表明根据刺激类型以及强度的神经反应的可分性。统计分析表明，环向放置的袖带触点比纵向放置的更可能导致更高的分类率。这种灵活的设置可以很容易地适用于啮齿动物中的各种电极和机械刺激的系统比较。因此，我们已将其机电设计和计算机程序放在网上
Considerable scientific and technological efforts are currently being made towards the development of neural prostheses. Understanding how the peripheral nervous system responds to electro-mechanical stimulation of the limb, will help to inform the design of prostheses that can restore function or accelerate recovery from injury to the sensory motor system. However, due to differences in experimental protocols, it is difficult, if not impossible, to make meaningful comparisons between different peripheral nerve interfaces. Therefore, we developed a low-cost electronic system to standardise the mechanical stimulation of a rat’s hindpaw. Three types of mechanical stimulations, namely, proprioception, touch and nociception were delivered to the limb and the electroneurogram signals were recorded simultaneously from the sciatic nerve with a 16-contact cuff electrode. For the first time, results indicate separability of neural responses according to stimulus type as well as intensity. Statistical analysis reveal that cuff contacts placed circumferentially, rather than longitudinally, are more likely to lead to higher classification rates. This flexible setup may be readily adapted for systematic comparison of various electrodes and mechanical stimuli in rodents. Hence, we have made its electro-mechanical design and computer programme available online
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影响因子：
17.1
作者：
Graczyk EL;Schiefer MA;Saal HP;Delhaye BP;Bensmaia SJ;Tyler DJ
通讯作者：
Tyler DJ
DOI：
10.1109/tnsre.2012.2217989
发表时间：
2013-01-01
影响因子：
4.9
作者：
Antfolk, Christian;D'Alonzo, Marco;Cipriani, Christian
通讯作者：
Cipriani, Christian
DOI：
10.1109/34.574797
发表时间：
1997-02-01
影响因子：
23.6
作者：
Jain, A;Zongker, D
通讯作者：
Zongker, D
影响因子：
1.2
作者：
Dweiri, Yazan M.;Stone, Matthew A.;Durand, Dominique M.
通讯作者：
Durand, Dominique M.
影响因子：
4
作者：
Koh, Ryan G. L.;Nachman, Adrian I.;Zariffa, Jose
通讯作者：
Zariffa, Jose