Engineering (Bio)Materials through Shrinkage and Expansion.

Engineering (Bio)Materials through Shrinkage and Expansion.
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DOI:
10.1002/adhm.202100380
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发表时间:
2021-07
影响因子:
10
通讯作者:
Zhang YS
Zhang YS
中科院分区:
工程技术1区
文献类型:
--
作者:
Wang M;Li W;Tang G;Garciamendez-Mijares CE;Zhang YS

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虽然各种(生物)制造技术在过去几十年中取得了革命性的进展,但工程结构仍然达不到预期,因为它们无法实现精确的可设计功能。可收缩和可膨胀(生物)材料具有独特的特性,导致尺寸/形状的变化,因此表现出强大的潜力,以装备当前的工程技术,促进生物医学应用的能力。在这份进展报告中,评估了各种刺激所能实现的尺寸/形状变化(生物)材料的进展;此外,还举例说明了与尺寸/形状变化(生物)材料相关的代表性生物医学应用。展望未来,尺寸/形状变化(生物)材料和3D/4D制造技术的结合为进一步开发复杂的功能架构提供了广泛的可能性。本进展报告系统地总结了用于工程(生物)材料的代表性尺寸/形状变化机制。凭借这种独特的可操作性,许多生物医学应用已经在组织工程,成像,药物输送,4D打印,医疗器械和纳米纤维等领域成为可能。
Although various (bio)fabrication technologies have achieved revolutionary progress in the past decades, engineered constructs still fall short of expectations owing to their inability to attain precisely designable functions. Shrinkable and expandable (bio)materials feature unique characteristics leading to size-/shape-shifting and thus have exhibited a strong potential to equip current engineering technologies with promoted capacities towards applications in biomedicine. In this Progress Report, the advances of size-/shape-shifting (bio)materials enabled by various stimuli, are evaluated; furthermore, representative biomedical applications associated with size-/shape-shifting (bio)materials are also exemplified. Towards the future, the combination of size-/shape-shifting (bio)materials and 3D/4D fabrication technologies presents a wide range of possibilities for further development of intricate functional architectures. This Progress Report systematically summarizes representative size-/shape-shifting mechanisms used towards engineering (bio)materials. With such unique maneuverability, numerous biomedical applications have been made possible in the fields of tissue engineering, imaging, drug delivery, 4D printing, medical device, and nanofabrication.
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