Central Retinal Vein Occlusion in a Young Woman with Diabetes and Hypertension after mRNA-Based COVID-19 Vaccination-A Case Report and Brief Review of the Literature.
Central Retinal Vein Occlusion in a Young Woman with Diabetes and Hypertension after mRNA-Based COVID-19 Vaccination-A Case Report and Brief Review of the Literature.
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DOI：
10.3390/vaccines11020365
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发表时间：
2023-02-05
期刊：
影响因子：
7.8
通讯作者：
Liu PK
中科院分区：
文献类型：
--
作者：
Sung SY;Jenny LA;Chang YC;Wang NK;Liu PK
一名患有糖尿病和高血压的25岁女性在接种第三剂SARS-CoV-2mRNA疫苗BNT162b2(辉瑞-生物科技)10天后出现左眼进行性无痛性视力模糊。临床检查证实视网膜中央静脉阻塞(CRVO)合并黄斑水肿的诊断。玻璃体腔内注射3种剂量的抗血管内皮生长因子(VEGF)。术后视力由术前的20/100提高到20/30，术后6个月复发。已有几例新冠肺炎疫苗接种后发生视网膜静脉阻塞的报道。然而，本病例是在接种SARS-CoV-2疫苗后记录的最年轻的CRVO女性个体。这一病例表明，接受SARS-CoV-2疫苗接种的有CRVO危险因素的患者黄斑水肿可能会复发，这表明需要仔细考虑治疗策略和密切随访。虽然确切的发病机制仍然需要仔细确定，但这份报告强调了RVO和基于mRNAs的新冠肺炎疫苗之间可能的关联，即使在年轻的个体中也是如此。
A 25-year-old female with diabetes and hypertension presented with progressive painless blurred vision in her left eye ten days after she received her third dose of the SARS-CoV-2 mRNA vaccine BNT162b2 (Pfizer-BioNTech). The clinical examination confirmed the diagnosis of Central Retinal Vein Occlusion (CRVO) complicated with macular edema. Three doses of anti-vascular endothelial growth factor (VEGF) were injected intravitreally. Visual acuity was improved from 20/100 to 20/30, but recurrence was noted at 6 months. Several cases of retinal vein occlusion (RVO) after COVID-19 vaccination have been reported. However, the present case is the youngest female individual documented to have CRVO after SARS-CoV-2 vaccination. This case demonstrates that the macular edema might be recurrent in patients with risk factors for CRVO who receive SARS-CoV-2 vaccination, suggesting the need for careful consideration of the treatment strategy and close follow-up. Although the definite pathogenesis still needs to be carefully determined, this report highlights the possible association between RVO and mRNA-based COVID-19 vaccination, even in young individuals.
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