Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis.
Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis.
复制标题
IL-4 和 IL-4 受体基因多态性与泌尿系癌之间的关联：荟萃分析。
DOI：
--
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Pang Jun
中科院分区：
文献类型：
--
作者：
Luo Yun;Ye Zhiqiang;Li Ke;Chen Ruihan;Li Shigeng;Pang Jun
未标记
通过Meta分析评价白细胞介素-4（IL-4）和白细胞介素-4受体（IL-4 R）基因多态性与肾细胞癌（RCC）、膀胱癌（BC）和前列腺癌（PC）风险的关系。PubMed、Web of Science和SpecilalSCI（TM）检索了截至2014年5月发表的报道IL-4或IL-4 R与RCC、BC或PC风险之间相关性的研究。分析比值比（OR）/风险比（HR）和95%置信区间（CI）以评估相关性。Meta分析结果显示IL-4 R基因rs 1805010多态性与肾细胞癌风险增加相关（CC/CT vs. TT：OR=1.266，95%CI 1.09-1.472，P=0.002）。IL-4单倍型IL-4 - 589 T和IL-4 - 33 T与IL-4- 589 C-33 C单倍型比较，生存率高（P<0.05）。IL-4基因多态性rs 2243250与多发性BC的发生风险增加相关（OR=2.52，P=0.033）。IL-4多态性rs 2243228、rs 2243250和rs 22272480与PC风险显著相关（rs 2243228 CC vs.
CA/AA
OR=0.27，95% CI 0.09-0.84，P=0.03; rs2243350 TT vs.
CT/CC
OR=2.16，95% CI 1.06-4.40，P=0.03，CC vs.
CT/TT
OR=1.31，95% CI 1.05-1.65，P=0.02; rs2227284 TT vs.
GT/GG
OR=1.98，95%CI 1.30-3.00，P=0.001）。此外，IL-4基因多态性rs 2070874与PC死亡率相关。三个多态性（rs 2070874，rs 1805015和rs 1801275）与RCC，BC和PC无关。IL-4 R基因多态性rs 1805015可能与肾细胞癌的发生有关。IL-4 rs 2243250携带者发生多个BC的风险增加。IL-4多态性rs 2243228、rs 2243250、rs 2227284和rs 2070874与PC风险或死亡率相关。
UNLABELLED
To evaluate the association between polymorphisms of interleukin-4 (IL-4) and IL-4 receptor (IL-4R) genes and risk of renal cell cancer (RCC), bladder cancer (BC), and prostate cancer (PC) based on meta-analysis. PubMed, Web of Science and SpecilalSCI(TM) were searched for studies published up to May 2014 that reported the association between IL-4 or IL-4R and RCC, BC or PC risk. Odds ratio (OR)/Hazard ratio (HR) and 95% confidence interval (CI) were analyzed to evaluate the association. Meta-analysis showed that the IL-4R polymorphism rs1805010 was associated with increased RCC risk (CC/CT vs. TT: OR=1.266, 95% CI 1.09-1.472, P=0.002). The IL-4 haplotypes, IL4-589T and IL4-33T, were associated with higher survival rate of the patients comparted with the haplotype IL-4-589C-33C (P<0.05). The IL-4 polymorphism rs2243250 was associated with an increased risk of developing multiple BCs (OR=2.52, P=0.033). The IL-4 polymorphisms rs2243228, rs2243250, and rs22272480 were significantly associated with PC risk (rs2243228 CC vs.
CA/AA
OR=0.27, 95% CI 0.09-0.84, P=0.03; rs2243350 TT vs.
CT/CC
OR=2.16, 95% CI 1.06-4.40, P=0.03, CC vs.
CT/TT
OR=1.31, 95% CI 1.05-1.65, P=0.02; rs2227284 TT vs.
GT/GG
OR=1.98, 95% CI 1.30-3.00, P=0.001). In addition, IL-4 polymorphism rs2070874 was associated with PC mortality. Three polymorphisms (rs2070874, rs1805015, and rs1801275) were not associated with RCC, BC, and PC. The IL-4R polymorphism rs1805015 might be associated with RCC risk. IL-4 rs2243250 carriers had increased risk of developing multiple BCs. IL-4 polymorphisms rs2243228, rs2243250, rs2227284, and rs2070874 were associated with PC risk or mortality.
登录
查看更多内容
DOI：
10.1158/1055-9965.epi-11-0236
发表时间：
2011-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Lin DW;FitzGerald LM;Fu R;Kwon EM;Zheng SL;Kolb S;Wiklund F;Stattin P;Isaacs WB;Xu J;Ostrander EA;Feng Z;Grönberg H;Stanford JL
通讯作者：
Stanford JL
影响因子：
--
作者：
S. Olson;I. Orlow;J. Simon;D. Tommasi;P. Roy;S. Bayuga;E. Ludwig;A. Zauber;R. Kurtz
通讯作者：
S. Olson;I. Orlow;J. Simon;D. Tommasi;P. Roy;S. Bayuga;E. Ludwig;A. Zauber;R. Kurtz
影响因子：
6.4
作者：
Castro, Felipe A.;Haimila, Katri;Pawlita, Michael
通讯作者：
Pawlita, Michael
影响因子：
5.8
作者：
Agarwal, A;Verma, S;Saxena, S
通讯作者：
Saxena, S
影响因子：
20.3
作者：
M. Beau;Richard S. Lemons;R. Espinosa;Richard A. Larson;N. Arai;Janet D. Rowley
通讯作者：
M. Beau;Richard S. Lemons;R. Espinosa;Richard A. Larson;N. Arai;Janet D. Rowley