Cocaine-induced plasticity, motivation, and cue responsivity do not differ in obesity-prone vs obesity-resistant rats; implications for food addiction.
Cocaine-induced plasticity, motivation, and cue responsivity do not differ in obesity-prone vs obesity-resistant rats; implications for food addiction.
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DOI：
10.1007/s00213-023-06327-5
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发表时间：
2023-04
影响因子：
3.4
通讯作者：
Ferrario, Carrie R.
中科院分区：
文献类型：
--
作者：
Saraswat, Anish A.;Longyear, Lauren G.;Kawa, Alex B.;Ferrario, Carrie R.
与肥胖抗性大鼠相比，肥胖倾向大鼠消耗更多的食物，更努力地获得食物，对食物线索表现出更大的动机反应，并且在食用含糖/高脂肪食物时表现出更大的纹状体可塑性。因此，肥胖倾向的大鼠也可能对可卡因和可卡因配对线索的动机特性以及可卡因诱导的可塑性更敏感。研究雄性肥胖易感大鼠与肥胖抵抗大鼠可卡因动机的基线差异，以及间歇性获取（IntA）可卡因自我给药对可卡因动机、对可卡因配对线索的神经行为反应和运动致敏的影响。采用静脉注射可卡因自我给药的方法检查男性吸毒和觅药情况。使用会话阈值程序测量可卡因的动机。测量线索诱导的中皮质边缘区c-Fos表达。在肥胖易感组和肥胖抵抗组之间，药物服用和药物寻找、线索诱导的c-Fos、运动致敏和可卡因消费偏好水平（Q0）相似。肥胖倾向大鼠需求测试时的最大反应（Rmax）较低。在肥胖倾向的大鼠中，IntA经历了对可卡因的动机增强（Pmax）。结果不支持肥胖易感大鼠与肥胖抵抗大鼠在可卡因动机、线索诱导的可卡因寻求或IntA诱导的神经行为可塑性方面存在强大的内在差异。这与之前在这些人群中发现的食物和食物线索的差异形成了对比，并表明食物和食物配对线索的内在动机增强不一定会转移到药物和药物配对线索上。在线版本包含补充材料，可在10.1007/s00213-023-06327-5获得。
Compared to obesity-resistant rats, obesity-prone rats consume more food, work harder to obtain food, show greater motivational responses to food-cues, and show greater striatal plasticity in response to eating sugary/fatty foods. Therefore, it is possible that obesity-prone rats may also be more sensitive to the motivational properties of cocaine and cocaine-paired cues, and to plasticity induced by cocaine. To examine baseline differences in motivation for cocaine and effects of intermittent access (IntA) cocaine self-administration on cocaine motivation, neurobehavioral responsivity to cocaine-paired cues, and locomotor sensitization in male obesity-prone vs obesity-resistant rats. Intravenous cocaine self-administration was used to examine drug-taking and drug-seeking in males. Motivation for cocaine was measured using a within session threshold procedure. Cue-induced c-Fos expression in mesocorticolimbic regions was measured. Drug-taking and drug-seeking, cue-induced c-Fos, locomotor sensitization, and preferred level of cocaine consumption (Q0) were similar between obesity-prone and obesity-resistant groups. Maximal responding during demand testing (Rmax) was lower in obesity-prone rats. IntA experience enhanced motivation for cocaine (Pmax) in obesity-prone rats. The results do not support robust inherent differences in motivation for cocaine, cue-induced cocaine seeking, or neurobehavioral plasticity induced by IntA in obesity-prone vs obesity-resistant rats. This contrasts with previously established differences seen for food and food cues in these populations and shows that inherent enhancements in motivation for food and food-paired cues do not necessarily transfer to drugs and drug-paired cues. The online version contains supplementary material available at 10.1007/s00213-023-06327-5.
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DOI：
10.1038/s41386-020-0781-1
发表时间：
2021-03
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Alonso-Caraballo Y;Fetterly TL;Jorgensen ET;Nieto AM;Brown TE;Ferrario CR
通讯作者：
Ferrario CR
影响因子：
3.4
作者：
Allain, Florence;Bouayad-Gervais, Karim;Samaha, Anne-Noel
通讯作者：
Samaha, Anne-Noel
影响因子：
3.4
作者：
Bentzley, Brandon S.;Fender, Kimberly M.;Aston-Jones, Gary
通讯作者：
Aston-Jones, Gary
影响因子：
2.7
作者：
Crombag, HS;Badiani, A;Robinson, TE
通讯作者：
Robinson, TE
影响因子：
3.4
作者：
Kawa, Alex B.;Valenta, Alec C.;Robinson, Terry E.
通讯作者：
Robinson, Terry E.