The behavioral economics of drug self-administration: a review and new analytical approach for within-session procedures.
The behavioral economics of drug self-administration: a review and new analytical approach for within-session procedures.
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DOI：
10.1007/s00213-012-2899-2
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发表时间：
2013-03
影响因子：
3.4
通讯作者：
Aston-Jones, Gary
中科院分区：
文献类型：
--
作者：
Bentzley, Brandon S.;Fender, Kimberly M.;Aston-Jones, Gary
关键词：
行为经济学需求曲线分析为药物自我给药提供了几种有用的测量方法。尽管之前生成需求曲线需要多天时间，但近期的单次实验阶段内程序允许从一次110分钟的可卡因自我给药实验阶段构建曲线，这使得行为经济学分析可用于广泛的自我给药实验。然而，对于单次实验阶段内的阈值程序，尚未有曲线拟合的数学方法的报道。
我们回顾了药物自我给药实验中的需求曲线分析，并提供了一种将曲线拟合到单次实验数据的定量方法，该方法纳入了脑部药物浓度的相对稳定性。
斯普拉格 - 道利大鼠被训练进行可卡因自我给药，然后用阈值程序进行测试，在该程序中，可卡因剂量按照固定比率1的时间表依次降低。在拟合曲线之前，去除处于相对不稳定的脑部可卡因浓度时的价格点（反应次数/毫克可卡因）。曲线拟合的准确性由低价（Q0）时可卡因消耗量的图形参数和计算参数之间的相关程度以及出现最大反应时的价格（Pmax）来确定。
去除处于相对不稳定的脑部可卡因浓度时的价格点，能精确估计Q0，并且得到的Pmax值与图形Pmax的一致性明显比传统方法更接近。
指数需求方程可以使用可卡因自我给药的阈值程序拟合到单次实验数据。去除处于相对不稳定的脑部可卡因浓度时的数据点，比图形方法能更准确地估计需求曲线的斜率，从而允许通过行为经济学框架对药物自我给药进行更全面的分析。
Behavioral-economic demand curve analysis offers several useful measures of drug self-administration. Although generation of demand curves previously required multiple days, recent within-session procedures allow curve construction from a single 110-min cocaine self-administration session, making behavioral-economic analyses available to a broad range of self-administration experiments. However, a mathematical approach of curve fitting has not been reported for the within-session threshold procedure. We review demand curve analysis in drug self-administration experiments and provide a quantitative method for fitting curves to single-session data that incorporates relative stability of brain drug concentration. Sprague-Dawley rats were trained to self-administer cocaine, and then tested with the threshold procedure in which the cocaine dose was sequentially decreased on a fixed ratio-1 schedule. Price points (responses/mg cocaine) outside of relatively stable brain cocaine concentrations were removed before curves were fit. Curve-fit accuracy was determined by the degree of correlation between graphical and calculated parameters for cocaine consumption at low price (Q0) and the price at which maximal responding occurred (Pmax). Removing price points that occurred at relatively unstable brain cocaine concentrations generated precise estimates of Q0 and resulted in Pmax values with significantly closer agreement with graphical Pmax than conventional methods. The exponential demand equation can be fit to single-session data using the threshold procedure for cocaine self-administration. Removing data points that occur during relatively unstable brain cocaine concentrations resulted in more accurate estimates of demand curve slope than graphical methods, permitting a more comprehensive analysis of drug self-administration via a behavioral-economic framework.
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影响因子：
3.6
作者：
Christensen, Chesley J.;Silberberg, Alan;Hursh, Steven R.;Roma, Peter G.;Riley, Anthony L.
通讯作者：
Riley, Anthony L.
影响因子：
6
作者：
MacKillop, James;O'Hagen, Sean;Monti, Peter M.
通讯作者：
Monti, Peter M.
影响因子：
3.4
作者：
Diergaarde, Leontien;van Mourik, Yvar;De Vries, Taco J.
通讯作者：
De Vries, Taco J.
影响因子：
6
作者：
Bickel, WK;Marsch, LA
通讯作者：
Marsch, LA
影响因子：
1.6
作者：
Galuska CM;Banna KM;Willse LV;Yahyavi-Firouz-Abadi N;See RE
通讯作者：
See RE