Procedural Performance Benefits after Excitotoxic Hippocampal Lesions in the Rat Sequential Reaction Time Task
Procedural Performance Benefits after Excitotoxic Hippocampal Lesions in the Rat Sequential Reaction Time Task
复制标题
大鼠序贯反应时间任务中兴奋性毒性海马损伤后的程序性能优势
DOI：
10.1007/s12640-015-9551-y
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发表时间：
2016
影响因子：
3.7
通讯作者：
Schwarting RKW
中科院分区：
文献类型：
--
作者：
Busse S ;Schwarting RKW
人们普遍认为，海马功能与各种物种（例如啮齿动物）的情节记忆和空间记忆有关。然而，海马功能与其他类型的学习和记忆（如程序性刺激反应或顺序学习）之间的相互作用尚不清楚。最近（Eckart等人，Hippocampus 22：1202-1214，2012），我们表明，主要影响其背侧部分的兴奋性毒性海马损伤不仅导致空间和情节样记忆任务（即物体位置识别测试）中的预期缺陷，而且还导致大鼠适应人类顺序反应时间任务（SRTT）的速度和准确性方面的实质性改善。然而，该实验的设计包括每个训练日固定的测试持续时间，这导致了这样一个事实，即受损动物获得了更多的工具经验，这可能部分解释了它们的表现增强。为了排除这种潜在的混淆，我们进行了本实验的大鼠与类似的ibotenic病变的目的是在背海马，但我们现在保持正确的仪器反应和增援的数量在相同的水平，在控制。我们的数据显示，与对照组和假手术组动物相比，病变组动物仍然能够在更短的时间内完成SRTT，尽管在速度或准确性方面没有观察到差异。此外，有病变的动物在随后的测试中表现出受损的灭绝，其中奖励被省略。前一种效应主要归因于损伤动物的强化后停顿时间较短，其可能机制和消退效应将在讨论中讨论。
It is widely agreed upon that hippocampal function is linked to episodic-like and spatial memory across various species, for example, rodents. However, the interplay between hippocampal function and other types of learning and memory, like procedural stimulus–response or sequential learning, is less clear. Recently (Eckart et al. in Hippocampus 22:1202–1214, 2012), we showed that excitotoxic hippocampal lesions, which mainly affected its dorsal part, led not only to the expected deficits in a spatial and episodic-like memory task, namely the object place recognition test, but also to substantial improvements in terms of speed and accuracy in a rat adaption of the human sequential reaction time task (SRTT). The design of that experiment, however, which included fixed test durations per training day, led to the fact that lesioned animals gained more instrumental experience, which may partly have accounted for their enhanced performance. In order to rule out such a potential confound, we performed the present experiment on rats with similar ibotenic lesions aiming at the dorsal hippocampus, but we now kept the amount of correct instrumental responses and reinforcements on the same level as in controls. Our data revealed that lesioned animals were still able to complete the SRTT in a substantially smaller amount of time, when compared to control and sham-operated animals, although no differences were observable in terms of speed or accuracy. Also, the animals with lesions showed impaired extinction in a subsequent test where rewards were omitted. The former effect can primarily be attributed to shorter post-reinforcement pauses in the lesioned animals, and the possible mechanisms of this and the extinction effect will be addressed in the discussion.
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影响因子：
--
作者：
C. Flicker;M. Geyer
通讯作者：
M. Geyer
海马切除和海马伞切断对大鼠部分强化消退效应的影响
影响因子：
2
作者：
J. Rawlins;J. Feldon,;J. Gray
通讯作者：
J. Gray
海马兴奋性毒性损伤后安非他明诱导的运动活性和伏核多巴胺释放的增强
影响因子：
2.7
作者：
L. Wilkinson;G. Mittleman;E. Torres;T. Humby;F. Hall;T. Robbins
通讯作者：
T. Robbins
老虎机赌博的动物模型：结构特征对响应延迟和持久性的影响
影响因子：
2.4
作者：
H. Peters;M. Hunt;D. Harper
通讯作者：
D. Harper
[海马在大脑整合活动中的作用]。
DOI：
--
发表时间：
1972
期刊：
Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova
影响因子：
--
作者：
P. Simonov
通讯作者：
P. Simonov