Age-related macular degeneration and mortality in older women: the study of osteoporotic fractures.
Age-related macular degeneration and mortality in older women: the study of osteoporotic fractures.
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DOI：
10.1111/jgs.13405
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发表时间：
2015-05
影响因子：
6.3
通讯作者：
Study of Osteoporotic Fractures Research Group
中科院分区：
文献类型：
--
作者：
Pedula KL;Coleman AL;Yu F;Cauley JA;Ensrud KE;Hochberg MC;Fink HA;Hillier TA;Study of Osteoporotic Fractures Research Group
研究老年女性中年龄相关性黄斑变性 (AMD) 与全因和特定原因死亡率的关系。前瞻性队列研究。美国四个临床中心 1202 名女性的随机样本，在骨质疏松性骨折研究第 10 年访视时拍摄了分级眼底照片（平均年龄 = 79.5 岁）。根据 AMD 的存在情况和严重程度（早期与晚期）对 45 度立体眼底照片进行分级。生命状况是根据死亡证明判定的。根据适当的混杂因素进行调整的 Cox 比例风险模型用于估计死亡率风险比。基线时，任何 AMD 的患病率为 40.5%，其中 441 人 (36.7%) 患有早期 AMD，46 人 (3.8%) 患有晚期 AMD。在超过 15 年的随访中，累积死亡率为 51.6%。总体而言，AMD 的存在或严重程度与全因或特定原因死亡率之间没有显着关联。由于 AMD 和年龄在预测死亡率方面存在显着的交互作用（每种死亡率类型 p<0.05），因此按年龄组对分析进行分层。在 80 岁以下的女性中，调整协变量后，晚期 AMD 与 CVD 死亡率相关（风险比 [HR]，2.61；95% 置信区间 [CI]，1.05–6.46）。在 80 岁及以上的女性中，早期 AMD 与全因死亡率（HR，1.39；95% CI，1.11-1.75）和非 CVD/非癌症（HR，1.45；95% CI，1.05-2.00）死亡率相关。此外，任何 AMD 都与 80 岁以上女性的全因死亡率（HR，1.42；95% CI，1.13-1.78）和 CVD（HR，1.45；95% CI，1.01-2.09）死亡率相关。 AMD 是女性生存率较差的预测因素，尤其是 80 岁或以上的女性。确定共同的风险因素可以确定新的干预途径，从而降低这两种情况的风险。
To examine the association of age-related macular degeneration (AMD) with all-cause and cause-specific mortality in a population of older women. Prospective cohort study. Four U.S. clinical centers A random sample of 1202 women with graded fundus photographs at year 10 visit of the Study of Osteoporotic Fractures (Mean age =79.5 years). Forty-five degree stereoscopic fundus photographs were graded for presence and severity (early vs. late) of AMD. Vital status was adjudicated from death certificates. Cox proportional hazards models, adjusted for appropriate confounders, were used to estimate mortality hazards ratios. Prevalence of any AMD was 40.5% at baseline, with 441 (36.7%) having early AMD and 46 (3.8%) having late AMD. Cumulative mortality was 51.6% in over 15 years of follow-up. Overall, there was no significant association between AMD presence or severity with all-cause or cause-specific mortality. Because there was a significant interaction between AMD and age in predicting mortality (p<0.05 for each mortality type) analyses were stratified by age group. Among women younger than 80 years, after adjusting for covariates, late AMD was associated with CVD mortality (Hazard ratio[HR], 2.61; 95% confidence interval [CI], 1.05–6.46). Among women 80 years and older, early AMD was associated with all-cause (HR, 1.39; 95% CI, 1.11–1.75)and non-CVD/non-cancer (HR, 1.45; 95% CI, 1.05–2.00) mortality. Additionally, any AMD was associated with all-cause (HR, 1.42; 95% CI, 1.13–1.78) and CVD (HR, 1.45; 95% CI, 1.01–2.09) mortality in women ≥ 80 years. AMD is a predictor of poorer survival among women, especially if 80 or older. Determination of shared risk factors may identify novel pathways for intervention that may reduce the risk of both conditions.
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影响因子：
13.7
作者：
Buch, H;Vinding, T;Nielsen, NV
通讯作者：
Nielsen, NV
DOI：
10.1111/j.1532-5415.2006.00983.x
发表时间：
2006-12-01
影响因子：
6.3
作者：
Pedula, Kathryn L.;Coleman, Anne L.;Mangione, Carol M.
通讯作者：
Mangione, Carol M.
影响因子：
120.7
作者：
NEVITT, MC;CUMMINGS, SR;BLACK, D
通讯作者：
BLACK, D
影响因子：
13.7
作者：
Milton, RC;Clemons, TE;Sperduto, RD
通讯作者：
Sperduto, RD
影响因子：
--
作者：
Ösby, U;Brandt, L;Sparén, P
通讯作者：
Sparén, P