An Aplysia Egr homolog is rapidly and persistently regulated by long-term sensitization training.
An Aplysia Egr homolog is rapidly and persistently regulated by long-term sensitization training.
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DOI：
10.1016/j.nlm.2013.03.008
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发表时间：
2013-05
影响因子：
2.7
通讯作者：
Calin-Jageman, Irina E.
中科院分区：
文献类型：
--
作者：
Cyriac, Ashly;Holmes, Geraldine;Lass, Jamie;Belchenko, Dmitry;Calin-Jageman, Robert J.;Calin-Jageman, Irina E.
Egr转录因子家族在许多脊椎动物物种的长期可塑性和记忆中起着关键作用。在这里，我们确定和表征ApEgr（基因库：KC 608221），Egr同源的海洋软体动物加州阿氏藻。ApEgr编码预测的593个氨基酸的蛋白质，其在C-末端具有高度保守的三个锌指结构域，其表征Egr家族的转录因子。启动子分析表明，ApEgr蛋白选择性识别脊椎动物Egr识别的GSG基序。与哺乳动物Egr一样，ApEgr在包括CNS在内的一系列组织中组成型表达。此外，ApEgr的表达受神经活动变化的双向调节。最感兴趣的是，ApEgr功能和记忆之间的关联可能是保守的，因为我们观察到长期敏化训练后表达的快速和持久的上调。综上所述，我们的研究结果表明，EGR可能具有从哺乳动物到软体动物都保守的记忆功能。
The Egr family of transcription factors plays a key role in long-term plasticity and memory in a number of vertebrate species. Here we identify and characterize ApEgr (GenBank: KC608221), an Egr homolog in the marine mollusk Aplysia californica. ApEgr codes for a predicted 593-amino acid protein with the highly conserved trio of zinc-fingered domains in the C-terminus that characterizes the Egr family of transcription factors. Promoter analysis shows that the ApEgr protein selectively recognizes the GSG motif recognized by vertebrate Egrs. Like mammalian Egrs, ApEgr is constitutively expressed in a range of tissues, including the CNS. Moreover, expression of ApEgr is bi-directionally regulated by changes in neural activity. Of most interest, the association between ApEgr function and memory may be conserved in Aplysia, as we observe rapid and long-lasting up-regulation of expression after long-term sensitization training. Taken together, our results suggest that Egrs may have memory functions that are conserved from mammals to mollusks.
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