The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas.
The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas.
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DOI：
10.7150/jca.5112
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发表时间：
2013
影响因子：
3.9
通讯作者：
Koontongkaew S
中科院分区：
文献类型：
--
作者：
Koontongkaew S
头颈部鳞状细胞癌（HNSCC）是一种复杂的组织，包含肿瘤细胞和周围的基质，其中由不同类型的间充质细胞和细胞外基质（ECM）填充。它们统称为肿瘤微环境（TME）。最近的研究表明，TME对HNSCC的生长和转移具有比以前认识到的更深刻的影响。由于癌相关的成纤维细胞（CAFs）经常观察到的肿瘤间质中，这篇评论的重点是肿瘤CAFs的相互作用在HNSCC的进展中的潜在作用。肿瘤-CAF串扰增强生长因子、细胞因子、趋化因子、基质金属蛋白酶（MMP）和炎症介质的产生，其最终促进肿瘤生长。事实上，不支持肿瘤生长的因子和细胞通常在TME中下调或减轻。因此，TME可能决定肿瘤在侵袭和转移部位的命运。对于在这些部位存活的肿瘤细胞，基质活化可用于建立支持性肿瘤基质，促进转移细胞的生长。肿瘤间质相互作用和微环境生态位的概念在肿瘤生长和转移中具有深远的影响，因此，对它的理解将为HNSCC的诊断、预后和治疗开辟新的策略。
Head and neck squamous cell carcinoma (HNSCC) is a complex tissue that contains tumor cells and the surrounding stroma, which is populated by different types of mesenchymal cells and the extracellular matrix (ECM). Collectively, they are referred to as the tumor microenvironment (TME). Recent studies have shown that TME has a more profound influence on the growth and metastasis of HNSCC than was previously appreciated. Because carcinoma-associated fibroblasts (CAFs) are frequently observed in the stroma of the tumor, this review focuses on the potential role of tumor-CAFs interactions in progression of HNSCC. Tumor-CAFs crosstalk enhances the production of growth factors, cytokines, chemokines, matrix metalloproteinases (MMPs), and inflammatory mediators, which eventually facilitates tumor growth. In fact, factors and cells that do not support tumor growth are usually down regulated or mitigated in TME. Therefore TME may determine the fate of the tumors at the site of invasion and metastasis. For tumor cells that survive at these sites, stromal activation may serve to establish a supportive tumor stroma, fostering the outgrowth of the metastatic cells. The concept of tumor-stromal interactions and microenvironmental niche has profound consequences in tumor growth and metastasis and therefore, it's understanding will open up new strategies for the diagnosis, prognosis and therapy of HNSCC.
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影响因子：
56.9
作者：
BROOKS, PC;CLARK, RAF;CHERESH, DA
通讯作者：
CHERESH, DA
影响因子：
1.9
作者：
Al-Hazmi, Nadia;Thomas, Gareth J.;Whawell, Simon A.
通讯作者：
Whawell, Simon A.
影响因子：
4.8
作者：
Chang, Kai-Ping;Kao, Huang-Kai;Yu, Jau-Song
通讯作者：
Yu, Jau-Song
影响因子：
14.5
作者：
Bourboulia D;Stetler-Stevenson WG
通讯作者：
Stetler-Stevenson WG
影响因子：
11.2
作者：
Albers, A;Abe, K;Ferris, RL
通讯作者：
Ferris, RL