The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans.
The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans.
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DOI：
10.3390/nu9101142
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发表时间：
2017-10-18
期刊：
影响因子：
5.9
通讯作者：
Koya D
中科院分区：
文献类型：
--
作者：
Kitada M;Ogura Y;Maruki-Uchida H;Sai M;Suzuki T;Kanasaki K;Hara Y;Seto H;Kuroshima Y;Monno I;Koya D
动物研究已经显示了Piceatannol对代谢健康的有益作用;然而，缺乏旨在检查这些作用的人体研究。本研究的目的是研究云杉醇对人类代谢健康的影响。这项随机、安慰剂对照研究在39名受试者中进行，包括10名超重男性和9名超重女性（BMI ≥ 25），以及10名非超重男性和10名非超重女性（BMI < 25）。受试者以随机顺序接受Piceatannol（20 mg/天）或安慰剂胶囊8周。主要结果是Piceatannol对葡萄糖代谢的影响，包括胰岛素敏感性。次要结果是对其他参数的影响，包括血压（BP），心率（HR），内皮功能，脂质，炎症，氧化应激，情绪状态，以及分离的外周血单核细胞（PBMNCs）中Sirt 1和磷酸化AMP激活激酶（p-AMPK）表达。在超重男性中补充Piceatannol降低了血清胰岛素水平、HOMA-IR、BP和HR。其他组，包括非超重男性，以及超重和非超重女性，对胰岛素敏感性、BP和HR没有显示出有益的影响。此外，Piceatannol与其他数据无关，包括体重（BW）、身体成分、内皮功能、脂质、炎症、氧化应激、情绪状态、和Sirt 1/p-AMPK表达。总之，补充Piceatannol可以改善超重男性的代谢健康，包括胰岛素敏感性，BP和HR。
Animal studies have shown the beneficial effects of piceatannol on metabolic health; however, there is a lack of human studies designed to examine these effects. The objective of this study was to investigate the effects of piceatannol on metabolic health in humans. This randomized, placebo-controlled study was conducted on 39 subjects, including 10 overweight men and 9 overweight women (BMI ≥ 25), as well as 10 non-overweight men and 10 non-overweight women (BMI < 25). Subjects received piceatannol (20 mg/day) or placebo capsules for eight weeks in a random order. The primary outcome was the effect of piceatannol on glucose-metabolism, including insulin sensitivity. The secondary outcomes were the effects on other parameters, including blood pressure (BP), heart rate (HR), endothelial function, lipids, inflammation, oxidative stress, mood status, and Sirt1 and phospho-AMP-activated kinase (p-AMPK) expression in isolated peripheral blood mononuclear cells (PBMNCs). Supplementation with piceatannol in overweight men reduced serum insulin levels, HOMA-IR, BP and HR. Other groups, including non-overweight men, as well as overweight and non-overweight women, showed no beneficial effects on insulin sensitivity, BP and HR. Furthermore, piceatannol is not associated with other data, including body weight (BW), body composition, endothelial function, lipids, inflammation, oxidative stress, mood status, and Sirt1/p-AMPK expression in PBMNCs. In conclusion, supplementation with piceatannol can improve metabolic health, including insulin sensitivity, BP and HR, in overweight men.
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影响因子：
2
作者：
Maruki-Uchida, Hiroko;Kurita, Ikuko;Ito, Tatsuhiko
通讯作者：
Ito, Tatsuhiko
影响因子：
5.9
作者：
Kawakami S;Kinoshita Y;Maruki-Uchida H;Yanae K;Sai M;Ito T
通讯作者：
Ito T
SIRT1 通过抑制 PTP1B 来改善胰岛素抵抗条件下的胰岛素敏感性。
影响因子：
29
作者：
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通讯作者：
Zhai, Qiwei
影响因子：
16.2
作者：
Larson-Meyer, D. Enette;Heilbronn, Leonie K.;Ravussin, Eric
通讯作者：
Ravussin, Eric
影响因子：
8.2
作者：
Ma, Hui-Juan;Cao, Ya-Kun;Wu, Yu-Ming
通讯作者：
Wu, Yu-Ming