Mass spectrometry imaging for drugs and metabolites.
Mass spectrometry imaging for drugs and metabolites.
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DOI:
10.1016/j.jprot.2011.03.032
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发表时间:
2011-11-18
影响因子:
3.3
通讯作者:
Li L
中科院分区:
文献类型:
--
作者:
Greer T;Sturm R;Li L
Mass spectrometric imaging (MSI) is a powerful analytical technique that provides two- and three-dimensional spatial maps of multiple compounds in a single experiment. This technique has been routinely applied to protein, peptide, and lipid molecules with much less research reporting small molecule distributions, especially pharmaceutical drugs. This review’s main focus is to provide readers with an up-to-date description of the substrates and compounds that have been analyzed for drug and metabolite composition using MSI technology. Additionally, ionization techniques, sample preparation, and instrumentation developments are discussed.
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