Mass spectrometry imaging for drugs and metabolites.

Mass spectrometry imaging for drugs and metabolites.
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DOI:
10.1016/j.jprot.2011.03.032
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发表时间:
2011-11-18
影响因子:
3.3
通讯作者:
Li L
Li L
中科院分区:
生物学2区
文献类型:
--
作者:
Greer T;Sturm R;Li L

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质谱成像(MSI)是一种强大的分析技术,可以在一次实验中提供多种化合物的二维和三维空间图。该技术已常规应用于蛋白质、肽和脂质分子,但小分子分布的研究较少,特别是药物。这篇综述的主要重点是为读者提供最新的底物和化合物的描述,这些底物和化合物已经使用MSI技术分析药物和代谢物组成。此外,电离技术,样品制备和仪器的发展进行了讨论。
Mass spectrometric imaging (MSI) is a powerful analytical technique that provides two- and three-dimensional spatial maps of multiple compounds in a single experiment. This technique has been routinely applied to protein, peptide, and lipid molecules with much less research reporting small molecule distributions, especially pharmaceutical drugs. This review’s main focus is to provide readers with an up-to-date description of the substrates and compounds that have been analyzed for drug and metabolite composition using MSI technology. Additionally, ionization techniques, sample preparation, and instrumentation developments are discussed.
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