Impaired physical function following pediatric LT.
Impaired physical function following pediatric LT.
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DOI：
10.1002/lt.24406
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发表时间：
2016-04
影响因子：
4.6
通讯作者：
Alonso, Estella M.
中科院分区：
文献类型：
--
作者：
Feldman, Amy G.;Neighbors, Katie;Mukherjee, Shubhra;Rak, Melanie;Varni, James W.;Alonso, Estella M.
调查儿科肝移植（LT）受者在LT后12-24个月的身体功能谱。回顾通过功能结局组收集的数据，功能结局组是儿科肝移植登记研究的辅助研究。如果患者在LT后存活12-24个月，则符合条件。≥ 8岁的儿童和父母完成了儿科生活质量量表™ 4.0通用核心量表，其中包括8个评估身体功能的问题。将评分与匹配的健康儿童人群（n=1658）进行比较，并在最佳健康与非最佳健康的幸存者之间进行比较。共纳入263例患者。移植和调查时的中位年龄分别为4.8岁（IQR 1.3-11.4）和5.9岁（IQR 2.6-13.1）。儿童和父母报告的平均身体功能评分分别为81.2± 17.3和77.1± 23.7。与匹配的健康人群相比，移植存活者及其父母报告的身体功能评分较低（p<0.01）。32.9%的患者和35.0%的父母报告身体功能评分<75，比健康人群的平均值低>1 SD。最佳健康状态的幸存者的身体功能评分显著高于非最佳健康状态的幸存者（p<0.01）。肝移植受者的情绪功能与躯体功能评分之间存在显著相关性（r=0.69，p<0.001）。在多变量分析中，原发疾病、长期随访（LTF）访视时身高Z评分<-1.64、自LTF访视以来住院≥4天、未列为状态1是身体功能不良的预测因素。LT后1-2年的儿科LT接受者及其父母报告的身体功能低于健康人群。研究结果表明，从业人员需要定期评估身体功能，康复计划的发展可能是重要的。
Investigate the spectrum of physical function of pediatric liver transplant (LT) recipients 12–24 months post-LT. Review data collected through the Functional Outcomes Group, an ancillary study of Studies of Pediatric Liver Transplantation registry. Patients were eligible if they had survived LT by 12–24 months. Children ≥ 8 years and parents completed the Pediatric Quality of Life Inventory™ 4.0 Generic Core Scales, which includes 8 questions assessing physical function. Scores were compared to a matched healthy child population (n=1658), and between survivors with optimal versus non-optimal health. A total of 263 patients were included. Median age at transplant and survey was 4.8 years (IQR 1.3–11.4) and 5.9 years (IQR 2.6–13.1), respectively. The mean Physical Functioning Score on child and parent reports were 81.2± 17.3 and 77.1± 23.7, respectively. Compared to a matched healthy population, transplant survivors and their parents reported lower physical function scores (p<0.01). 32.9% of patients and 35.0% of parents reported a physical function score <75, which is >1 SD below the mean of a healthy population. Physical Function Scores were significantly higher in survivors with optimal health than those with non-optimal health (p<0.01). There was a significant relationship between Emotional Functioning and Physical Functioning Scores for LT recipients (r=0.69, p<0.001). In multivariate analysis, primary disease, height Z score<−1.64 at long term follow-up (LTF) visit, ≥4 days of hospitalization since LTF visit, and not listed as Status 1 were predictors of poor physical function. Pediatric LT recipients 1–2 years post-LT and their parents report lower physical function than a healthy population. Findings suggest practitioners need to routinely assess physical function, and development of rehabilitation programs may be important.
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影响因子：
4.3
作者：
Khera, Nandita;Chow, Eric J.;Lee, Stephanie J.
通讯作者：
Lee, Stephanie J.
影响因子：
5.1
作者：
Ng, Vicky L.;Alonso, Estella M.;Bucuvalas, John C.;Cohen, Geoff;Limbers, Christine A.;Varni, James W.;Mazariegos, George;Magee, John;McDiarmid, Susan V.;Anand, Ravinder
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影响因子：
9.6
作者：
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通讯作者：
ARMITAGE, JM
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影响因子：
120.7
作者：
Mora, S;Redberg, RF;Blumenthal, RS
通讯作者：
Blumenthal, RS
影响因子：
3
作者：
Varni, JW;Seid, M;Kurtin, PS
通讯作者：
Kurtin, PS