Rapid Antibody-Based COVID-19 Mass Surveillance: Relevance, Challenges, and Prospects in a Pandemic and Post-Pandemic World.
Rapid Antibody-Based COVID-19 Mass Surveillance: Relevance, Challenges, and Prospects in a Pandemic and Post-Pandemic World.
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基于快速抗体的Covid-19质量监测：大流行和大流行世界中的相关性，挑战和前景。
DOI：
10.3390/jcm9103372
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发表时间：
2020-10-21
影响因子：
3.9
通讯作者：
Kevadiya BD
中科院分区：
文献类型：
--
作者：
Augustine R;Das S;Hasan A;S A;Abdul Salam S;Augustine P;Dalvi YB;Varghese R;Primavera R;Yassine HM;Thakor AS;Kevadiya BD
严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)作为新冠肺炎(CoronaVirus Disease-2019年)大流行的咄咄逼人的爆发需要快速和简化的检测工具来有效管理它。增加大规模检测和监测对于控制疾病传播、获得更好的大流行统计数据和发展现实的流行病学模型至关重要。尽管基于核酸和抗原的检测具有准确性、特异性和非侵入性的样本采集方法等优点，但它们只能检测活动性感染。抗体(免疫球蛋白)是由宿主免疫系统在感染后几天内产生的，并在感染消退后在血液中持续至少几周。过去，基于抗体的检测为包括SARS(严重急性呼吸综合征)和MERS(中东呼吸综合征)等病毒性疾病在内的多种传染病暴发提供了一种替代和有效的超快速检测方法。因此，虽然不太适合早期诊断，但基于抗体的方法可以用来检测隐藏在人群中的过去感染，包括无症状的感染。在疾病活跃的社区传播情景中，可以为大规模检测提供更大的窗口，并为持续监测提供一种实用的方法。这些因素鼓励研究人员研究改进基于抗体的快速检测的方法，并将其用作新冠肺炎大规模检测和监测的可靠、可重复、敏感、特异和经济的工具。这种基于免疫球蛋白的检测的开发和整合可以通过将其从诊所和实验室转移到社区检测地点和家庭来改变大流行诊断。本文就目前抗体检测的原理、技术和策略作一综述。它还强调了基于免疫球蛋白的检测的巨大前景，以及在全球大流行管理和大流行后可持续筛查中重复计划部署的有效性。
The aggressive outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as COVID-19 (coronavirus disease-2019) pandemic demands rapid and simplified testing tools for its effective management. Increased mass testing and surveillance are crucial for controlling the disease spread, obtaining better pandemic statistics, and developing realistic epidemiological models. Despite the advantages of nucleic acid- and antigen-based tests such as accuracy, specificity, and non-invasive approaches of sample collection, they can only detect active infections. Antibodies (immunoglobulins) are produced by the host immune system within a few days after infection and persist in the blood for at least several weeks after infection resolution. Antibody-based tests have provided a substitute and effective method of ultra-rapid detection for multiple contagious disease outbreaks in the past, including viral diseases such as SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome). Thus, although not highly suitable for early diagnosis, antibody-based methods can be utilized to detect past infections hidden in the population, including asymptomatic ones. In an active community spread scenario of a disease that can provide a bigger window for mass detections and a practical approach for continuous surveillance. These factors encouraged researchers to investigate means of improving antibody-based rapid tests and employ them as reliable, reproducible, sensitive, specific, and economic tools for COVID-19 mass testing and surveillance. The development and integration of such immunoglobulin-based tests can transform the pandemic diagnosis by moving the same out of the clinics and laboratories into community testing sites and homes. This review discusses the principle, technology, and strategies being used in antibody-based testing at present. It also underlines the immense prospect of immunoglobulin-based testing and the efficacy of repeated planned deployment in pandemic management and post-pandemic sustainable screenings globally.
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DOI：
10.1080/08998280.2020.1731272
发表时间：
2020-04-01
期刊：
Proceedings (Baylor University. Medical Center)
影响因子：
--
作者：
Columbus, Cristie;Brust, Karen B;Arroliga, Alejandro C
通讯作者：
Arroliga, Alejandro C
影响因子：
6.4
作者：
Cai, Xue-fei;Chen, Juan;Wang, De-qiang
通讯作者：
Wang, De-qiang
影响因子：
5.5
作者：
Andrey, Diego O.;Cohen, Patrick;Vuilleumier, Nicolas
通讯作者：
Vuilleumier, Nicolas
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
影响因子：
15.9
作者：
BERSON, SA;YALOW, RS
通讯作者：
YALOW, RS