Nanoparticle-based drug delivery to the vagina: a review.
Nanoparticle-based drug delivery to the vagina: a review.
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DOI：
10.1016/j.jconrel.2014.04.033
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发表时间：
2014-09-28
期刊：
影响因子：
--
通讯作者：
Hanes J
中科院分区：
文献类型：
--
作者：
Ensign LM;Cone R;Hanes J
阴道给药可以改善对影响女性生殖道的许多疾病的预防和治疗，包括性传播疾病、真菌和细菌感染以及癌症。然而，由于阴道上皮的高渗透性和常规可溶性药物剂型的排出，在阴道中实现持续的局部药物浓度可能具有挑战性。基于纳米颗粒的药物递送平台对于阴道药物递送已经受到相当大的关注，因为纳米颗粒可以提供持续释放、细胞靶向、甚至内在的抗微生物或佐剂性质，其可以提高预防和治疗方式的效力和/或功效。在这里，我们回顾了聚合物纳米颗粒、脂质体、树枝状聚合物和无机纳米颗粒在阴道给药中的应用。虽然大多数基于纳米颗粒的阴道给药工作都集中在艾滋病毒预防上，但治疗和预防其他性传播感染、治疗生殖道癌症以及治疗真菌和细菌感染的策略也得到了重视。
Vaginal drug administration can improve prophylaxis and treatment of many conditions affecting the female reproductive tract, including sexually transmitted diseases, fungal and bacterial infections, and cancer. However, achieving sustained local drug concentrations in the vagina can be challenging, due to the high permeability of the vaginal epithelium and expulsion of conventional soluble drug dosage forms. Nanoparticle-based drug delivery platforms have received considerable attention for vaginal drug delivery, as nanoparticles can provide sustained release, cellular targeting, and even intrinsic antimicrobial or adjuvant properties that can improve the potency and/or efficacy of prophylactic and therapeutic modalities. Here, we review the use of polymeric nanoparticles, liposomes, dendrimers, and inorganic nanoparticles for vaginal drug delivery. Although most of the work toward nanoparticle-based drug delivery in the vagina has been focused on HIV prevention, strategies for treatment and prevention of other sexually transmitted infections, treatment for reproductive tract cancer, and treatment of fungal and bacterial infections are also highlighted.
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