Risk factors for the development of orthostatic hypotension during autologous stem cell transplant in patients with multiple myeloma.
Risk factors for the development of orthostatic hypotension during autologous stem cell transplant in patients with multiple myeloma.
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DOI：
10.1080/10428194.2022.2084729
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发表时间：
2022-10
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
直立性低血压（OH）是接受自体干细胞移植（ASCT）的多发性骨髓瘤（MM）患者中公认的现象，与显著的发病率和死亡率相关。对2012年6月至2014年4月期间首次ASCT入院的患者进行的回顾性分析发现，161/222（73%）例患者在ASCT期间被诊断为OH，包括51例在首次直立生命体征检查当天被发现患有OH的患者。排除这51例患者后，110/171例（64%）患者在围移植期发生OH，中位时间为ASCT后7天（95% CI：6.5-8.5）。OH对住院时间、无进展生存期和总生存期无显著影响。多变量分析显示与移植术前后OH发生相关的4个风险因素（即体重减轻≥0.5%/天、白色人种、加巴喷丁、抗高血压药）和2个保护因素（即抗组胺药、质子泵抑制剂）。
Orthostatic hypotension (OH) is a well-recognized phenomenon occurring in multiple myeloma (MM) patients undergoing autologous stem cell transplant (ASCT), and is associated with significant morbidity and mortality. A retrospective analysis of patients admitted for first ASCT between June 2012 and April 2014 found that 161/222 (73%) patients were diagnosed with OH during the course of ASCT, including 51 patients who were found to have OH on the day of first orthostatic vitals check. Excluding these 51 patients, 110/171 (64%) patients developed OH during the peri-transplant period, at a median of 7 days post ASCT (95% CI: 6.5–8.5). OH did not significantly impact length of hospitalization, progression free and overall survival. Multivariable analysis revealed four risk factors (i.e. ≥0.5% weight loss/day, white race, gabapentin, antihypertensives) and two protective factors (i.e. antihistamine, proton pump inhibitor) associated with the development of peri-transplant OH.
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影响因子：
1.9
作者：
Chen, Hsin-Hung;Li, Yih-Do;Yeh, Tung-Chen
通讯作者：
Yeh, Tung-Chen
DOI：
10.1111/j.1532-5415.1991.tb03593.x
发表时间：
1991-06-01
影响因子：
6.3
作者：
STROGATZ, DS;KEENAN, NL;WAGNER, EH
通讯作者：
WAGNER, EH
影响因子：
6.5
作者：
Kazandjian D;Mo CC;Landgren O;Richardson PG
通讯作者：
Richardson PG
DOI：
10.1001/jama.1965.03090110061015
发表时间：
1965-01-01
影响因子：
--
作者：
KLIGMAN, AM
通讯作者：
KLIGMAN, AM
神经源性体性低血压：病理生理，评估和管理。
影响因子：
6
作者：
Metzler M;Duerr S;Granata R;Krismer F;Robertson D;Wenning GK
通讯作者：
Wenning GK