The association between OGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis of 27 studies.
The association between OGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis of 27 studies.
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DOI：
10.1371/journal.pone.0035970
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yu SQ
中科院分区：
文献类型：
--
作者：
Duan WX;Hua RX;Yi W;Shen LJ;Jin ZX;Zhao YH;Yi DH;Chen WS;Yu SQ
已有多项研究探讨了OGG1Ser326Cys基因多态与肺癌易感性的关系，但研究结果并不一致。因此，我们在27篇文献的基础上进行了荟萃分析，包括9,663个病例和11348个对照，以全面评估这些关联。我们检索了MEDLINE和EMBASE的文章，这些文章正在评估OGG1Ser326Cys多态与肺癌风险的关系。采用固定效应模型和随机效应模型计算合并优势比(OR)和95%可信区间(CI)。我们使用了来自HapMap的SNP rs1052133在正常细胞系中的基于基因型的mRNA表达数据，这些细胞系来自四个不同种族的270名受试者。结果表明，携带Cys/Cys基因的个体与Ser/Ser基因携带者相比，患肺癌的风险无显著增加(OR = 1.15，95%CI = 0.98~1.36)；同样，在隐性、显性或杂合性共显性模式(Ser/Cys vs.Cys/Cys)中未发现显著关联。然而，相对较大的样本量(Ser/Ser vs Cys/Cys：or = 1.29，95%CI = 1.13~1.48；或隐性模型：or = 1.19，95%CI = 1.07~1.32)的风险显著增加。在组织学类型上，发现Cys/Cys与腺癌风险相关(Ser/Ser vs Cys/Cys：OR = 1.32，95%CI = 1.12~1.56；Ser/Cys vs Cys/Cys：OR = 1.19，95%CI = 1.04~1.37；隐性模型OR = 1.23，95%CI = 1.08~1.40)。不同种族间OGG1基因表达差异无统计学意义。尽管存在一些局限性，但这一荟萃分析为OGG1Cys/Cys基因与肺癌风险之间的关联建立了坚实的统计学证据，特别是在大样本量和腺癌的研究中，但这种关联值得在更大规模和设计良好的研究中进一步验证。
Numerous studies have investigated association of OGG1 Ser326Cys polymorphism with lung cancer susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis based on 27 publications encompass 9663 cases and 11348 controls to comprehensively evaluate such associations. We searched publications from MEDLINE and EMBASE which were assessing the associations between OGG1 Ser326Cys polymorphism and lung cancer risk. We calculated pooled odds ratio (OR) and 95% confidence interval (CI) by using either fixed-effects or random-effects model. We used genotype based mRNA expression data from HapMap for SNP rs1052133 in normal cell lines among 270 subjects with four different ethnicities. The results showed that individuals carrying the Cys/Cys genotype did not have significantly increased risk for lung cancer (OR = 1.15, 95% CI = 0.98–1.36) when compared with the Ser/Ser genotype; similarly, no significant association was found in recessive, dominant or heterozygous co-dominant model (Ser/Cys vs. Cys/Cys). However, markedly increased risks were found in relatively large sample size (Ser/Ser vs. Cys/Cys: OR = 1.29, 95% CI = 1.13–1.48, and recessive model: OR = 1.19, 95% CI = 1.07–1.32). As to histological types, we found the Cys/Cys was associated with adenocarcinoma risk (Ser/Ser vs. Cys/Cys: OR = 1.32, 95% CI = 1.12–1.56; Ser/Cys vs. Cys/Cys: OR = 1.19, 95% CI = 1.04–1.37, and recessive model OR = 1.23, 95% CI = 1.08–1.40). No significant difference of OGG1 mRNA expression was found among genotypes between different ethnicities. Despite some limitations, this meta-analysis established solid statistical evidence for an association between the OGG1 Cys/Cys genotype and lung cancer risk, particularly for studies with large sample size and adenocarcinoma, but this association warrants additional validation in larger and well designed studies.
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影响因子：
64.8
作者：
Frazer, Kelly A.;Ballinger, Dennis G.;Cox, David R.;Hinds, David A.;Stuve, Laura L.;Gibbs, Richard A.;Belmont, John W.;Boudreau, Andrew;Hardenbol, Paul;Leal, Suzanne M.;Pasternak, Shiran;Wheeler, David A.;Willis, Thomas D.;Yu, Fuli;Yang, Huanming;Zeng, Changqing;Gao, Yang;Hu, Haoran;Hu, Weitao;Li, Chaohua;Lin, Wei;Liu, Siqi;Pan, Hao;Tang, Xiaoli;Wang, Jian;Wang, Wei;Yu, Jun;Zhang, Bo;Zhang, Qingrun;Zhao, Hongbin;Zhao, Hui;Zhou, Jun;Gabriel, Stacey B.;Barry, Rachel;Blumenstiel, Brendan;Camargo, Amy;Defelice, Matthew;Faggart, Maura;Goyette, Mary;Gupta, Supriya;Moore, Jamie;Nguyen, Huy;Onofrio, Robert C.;Parkin, Melissa;Roy, Jessica;Stahl, Erich;Winchester, Ellen;Ziaugra, Liuda;Altshuler, David;Shen, Yan;Yao, Zhijian;Huang, Wei;Chu, Xun;He, Yungang;Jin, Li;Liu, Yangfan;Shen, Yayun;Sun, Weiwei;Wang, Haifeng;Wang, Yi;Wang, Ying;Xiong, Xiaoyan;Xu, Liang;Waye, Mary M. Y.;Tsui, Stephen K. W.;Wong, J. Tze-Fei;Galver, Luana M.;Fan, Jian-Bing;Gunderson, Kevin;Murray, Sarah S.;Oliphant, Arnold R.;Chee, Mark S.;Montpetit, Alexandre;Chagnon, Fanny;Ferretti, Vincent;Leboeuf, Martin;Olivier, Jean-Franccois;Phillips, Michael S.;Roumy, Stephanie;Sallee, Clementine;Verner, Andrei;Hudson, Thomas J.;Kwok, Pui-Yan;Cai, Dongmei;Koboldt, Daniel C.;Miller, Raymond D.;Pawlikowska, Ludmila;Taillon-Miller, Patricia;Xiao, Ming;Tsui, Lap-Chee;Mak, William;Song, You Qiang;Tam, Paul K. H.;Nakamura, Yusuke;Kawaguchi, Takahisa;Kitamoto, Takuya;Morizono, Takashi;Nagashima, Atsushi;Ohnishi, Yozo;Sekine, Akihiro;Tanaka, Toshihiro;Tsunoda, Tatsuhiko;Deloukas, Panos;Bird, Christine P.;Delgado, Marcos;Dermitzakis, Emmanouil T.;Gwilliam, Rhian;Hunt, Sarah;Morrison, Jonathan;Powell, Don;Stranger, Barbara E.;Whittaker, Pamela;Bentley, David R.;Daly, Mark J.;de Bakker, Paul I. W.;Barrett, Jeff;Chretien, Yves R.;Maller, Julian;McCarroll, Steve;Patterson, Nick;Pe'er, Itsik;Price, Alkes;Purcell, Shaun;Richter, Daniel J.;Sabeti, Pardis;Saxena, Richa;Schaffner, Stephen F.;Sham, Pak C.;Varilly, Patrick;Altshuler, David;Stein, Lincoln D.;Krishnan, Lalitha;Smith, Albert Vernon;Tello-Ruiz, Marcela K.;Thorisson, Gudmundur A.;Chakravarti, Aravinda;Chen, Peter E.;Cutler, David J.;Kashuk, Carl S.;Lin, Shin;Abecasis, Goncalo R.;Guan, Weihua;Li, Yun;Munro, Heather M.;Qin, Zhaohui Steve;Thomas, Daryl J.;McVean, Gilean;Auton, Adam;Bottolo, Leonardo;Cardin, Niall;Eyheramendy, Susana;Freeman, Colin;Marchini, Jonathan;Myers, Simon;Spencer, Chris;Stephens, Matthew;Donnelly, Peter;Cardon, Lon R.;Clarke, Geraldine;Evans, David M.;Morris, Andrew P.;Weir, Bruce S.;Tsunoda, Tatsuhiko;Johnson, Todd A.;Mullikin, James C.;Sherry, Stephen T.;Feolo, Michael;Skol, Andrew
通讯作者：
Skol, Andrew
影响因子：
5
作者：
Chang, Chin-Hao;Hsiao, Chin-Fu;Hsiung, Chao A.
通讯作者：
Hsiung, Chao A.
DOI：
10.1016/j.mrfmmm.2011.02.009
发表时间：
2011-05-10
影响因子：
2.3
作者：
Janik, Justyna;Swoboda, Maja;Speina, Elzbieta
通讯作者：
Speina, Elzbieta
DOI：
10.1016/j.mrfmmm.2007.11.002
发表时间：
2008-03-01
影响因子：
2.3
作者：
Hatt, Lotte;Loft, Steffen;Vogel, Ulla
通讯作者：
Vogel, Ulla
影响因子：
3
作者：
Holm K;Melum E;Franke A;Karlsen TH
通讯作者：
Karlsen TH