Synchrony of telomere length among hematopoietic cells.
Synchrony of telomere length among hematopoietic cells.
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DOI：
10.1016/j.exphem.2010.06.010
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发表时间：
2010-10
影响因子：
2.6
通讯作者：
Aviv, Abraham
中科院分区：
文献类型：
--
作者：
Kimura, Masayuki;Gazitt, Yair;Cao, Xiaojian;Zhao, Xiangru;Lansdorp, Peter M.;Aviv, Abraham
关于白细胞亚群之间以及白细胞和造血细胞之间端粒长度的关系，我们所知甚少。这一信息是相关的，因为粒细胞的端粒动力学被认为反映了造血干细胞（hsc）的动态。我们检测了新生儿脐带血（UCB）中造血祖细胞（HPCs） （CD34+CD45−）端粒长度与T淋巴细胞和粒细胞端粒长度的关系。此外，我们将粒细胞的端粒长度与年龄范围从出生到100岁的个体的整个白细胞样本的端粒长度联系起来。在UCB中，我们发现HPCs端粒长度与T淋巴细胞端粒长度（r= 0.882-0.935, p= 0.0038-0.0007）和粒细胞端粒长度（r=0.930, p=0.0072）有很强的相关性。出生时，粒细胞端粒长度与所有白细胞端粒长度也有很强的相关性（r=0.979, p=0.0003）。在整个人的一生中，粒细胞端粒长度与所有白细胞端粒长度之间的关系为r>0.980, p<0.0001。在整个人的一生中，白细胞亚群之间存在着强大的同步性；在一个白细胞亚群中端粒较长（或较短）的个体在其他白细胞亚群中端粒较长（或较短）。此外，白细胞中的端粒长度反映了其在造血层次上的细胞中的长度，即HPCs和由此推断的hsc。许多研究发现白细胞端粒长度与许多衰老相关疾病之间存在密切联系。因此，我们的研究结果表明，这些联系可能追溯到造血干细胞的端粒动力学。
Little is known about the relations of telomere lengths among leukocyte subsets and between leukocytes and cells up the hematopoietic hierarchy. This information is relevant, since telomere dynamics in granulocytes were postulated to mirror those of hematopoietic stem cells (HSCs). We examined in newborns’ cord blood (UCB) the relationships of telomere length in hematopoietic progenitor cells (HPCs) (CD34+CD45−) with that in T lymphocytes and in granulocytes. In addition, we correlated telomere length in granulocytes with that in whole leukocyte samples of individuals with age range between birth and 100 years. In the UCB, we found strong correlations of telomere length in HPCs with telomere lengths in T lymphocytes (r ranging from 0.882–0.935, p ranging from 0.0038–0.0007) and in granulocytes (r=0.930, p=0.0072). At birth, strong correlations were also observed between telomere length in granulocytes and that in all leukocytes (r=0.979, p=0.0003). Throughout the human lifespan, the relationship between telomere length in granulocytes and that in all leukocytes was r>0.980, p<0.0001. Robust synchrony exists among leukocyte subsets throughout the human lifespan; individuals with relatively long (or short) telomeres in one leukocyte subset have long (or short) telomeres in other leukocyte subsets. Moreover, telomere length in leukocytes reflects its length in cells up the hematopoietic hierarchy, i.e., HPCs and, by inference, HSCs. Strong links have been found by many studies between leukocyte telomere length and a host of aging-related diseases. Our findings suggest, therefore, that that these links might be traced to telomere dynamics in HSCs.
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影响因子：
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作者：
Vasa-Nicotera, M;Brouilette, S;Samani, NJ
通讯作者：
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影响因子：
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