A case-control analysis of traceback investigations for Vibrio parahaemolyticus infections (vibriosis) and pre-harvest environmental conditions in Washington State, 2013-2018.
A case-control analysis of traceback investigations for Vibrio parahaemolyticus infections (vibriosis) and pre-harvest environmental conditions in Washington State, 2013-2018.
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DOI：
10.1016/j.scitotenv.2020.141650
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发表时间：
2021-01-15
期刊：
影响因子：
--
通讯作者：
Curriero FC
中科院分区：
文献类型：
--
作者：
Davis BJK;Corrigan AE;Sun Z;Atherly E;DePaola A;Curriero FC
副溶血弧菌是海鲜传播疾病的主要原因。它在咸水中自然流行，并在贝类中积累。全球弧菌病病例正在增加，可能是由于气温上升。旨在确定华盛顿州弧菌病与收获前环境和从贝类中取样的副溶血弧菌遗传测量之间的关联。成功的弧菌病追溯调查与常规潮间带牡蛎（Crassostrea gigas）采样事件在时空上相匹配，其中包括温度、盐度和副溶血性弧菌遗传目标的测量（耐热溶血素：tlh；耐热直接溶血素：tdh；耐热直接相关溶血素：trh）。不匹配的采样事件被视为对照。使用逻辑回归模型评估关联性。在华盛顿各收获区观察到系统性差异。其中包括南普吉特湾弧菌病发生几率与所有三个遗传目标之间的正相关性，当总细菌丰度较低时（tlh <1 log10 MPN/g），tdh 增加 1-log10 时，比值比 (OR) = 13.0（95% CI：1.5，115.0）。组织温度增加 1°C 也出现正相关 OR=1.20 (95% CI: 1.10, 1.30)，而水温类似增加 OR= 0.70 则出现负相关 (95% CI: 0.59, 0.81)。相比之下，沿海海湾与水温 OR= 2.16 (95% CI: 1.15, 4.05) 呈正相关，并且 tdh:trh 比率增加 1-log10 OR= 5.85 (95% CI: 1.06, 32.26)。关联中的区域变化表明独特的致病菌株突出，表明南普吉特海湾存在 tdh+/trh+ 菌株，例如 O4:K12 血清型，以及沿海海湾的 tdh+/trh− 菌株。水和牡蛎组织之间的温度差异表明，南普吉特湾致病菌株在低潮期间接触相对温暖的空气时会大量繁殖。这些发现确定了华盛顿州弧菌病的新生态风险因素，可用于未来的预防工作。
Vibrio parahaemolyticus is a major cause of seafood-borne illness. It is naturally prevalent in brackish waters and accumulates in shellfish. Vibriosis cases are rising globally, likely due to rising temperatures. To identify associations between vibriosis in Washington State and pre-harvest environmental and V. parahaemolyticus genetic measurements sampled from shellfish. Successful vibriosis traceback investigations were spatiotemporally matched to routine intertidal oyster (Crassostrea gigas) sampling events, which included measurements of temperature, salinity, and V. parahaemolyticus genetic targets (thermolabile hemolysin: tlh; thermostable direct hemolysin: tdh; thermostable direct-related hemolysin: trh). Unmatched sampling events were treated as controls. Associations were evaluated using logistic regression models. Systematic differences were observed across Washington harvesting zones. These included positive associations between the odds of vibriosis and all three genetic targets in South Puget Sound, with a large odds ratio (OR) = 13.0 (95% CI: 1.5, 115.0) for a 1-log10 increase in tdh when total bacterium abundance was low (tlh <1 log10 MPN/g). A positive association also occurred for a 1°C increase in tissue temperature OR=1.20 (95% CI: 1.10, 1.30) while a negative association occurred for a similar increase in water temperature OR= 0.70 (95% CI: 0.59, 0.81). In contrast, the coastal bays displayed positive associations for water temperature OR= 2.16 (95% CI: 1.15, 4.05), and for a 1-log10 increase in the tdh:trh ratio OR= 5.85 (95% CI: 1.06, 32.26). The zonal variation in associations indicates unique pathogenic strain prominence, suggesting tdh+/trh+ strains in South Puget Sound, such as the O4:K12 serotype, and tdh+/trh− strains in the coastal bays. The temperature discrepancy between water and oyster tissue suggests that South Puget Sound pathogenic strains flourish with exposure to relatively warm air during low tide. These findings identify new ecological risk factors for vibriosis in Washington State that can be used in future prevention efforts.
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影响因子：
6.4
作者：
Daniels, NA;MacKinnon, L;Slutsker, L
通讯作者：
Slutsker, L
影响因子：
5.2
作者：
Flynn, Aspen;Davis, Benjamin J. K.;Curriero, Frank C.
通讯作者：
Curriero, Frank C.
影响因子：
4.4
作者：
Jones, J. L.;Kinsey, T. P.;Bowers, J. C.
通讯作者：
Bowers, J. C.
DOI：
10.1186/s12940-017-0301-x
发表时间：
2017-08-31
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Konrad S;Paduraru P;Romero-Barrios P;Henderson SB;Galanis E
通讯作者：
Galanis E
影响因子：
4
作者：
Jacobs, J. M.;Rhodes, M.;Wood, R.
通讯作者：
Wood, R.