Non-Sinusoidal Activity Can Produce Cross-Frequency Coupling in Cortical Signals in the Absence of Functional Interaction between Neural Sources.
Non-Sinusoidal Activity Can Produce Cross-Frequency Coupling in Cortical Signals in the Absence of Functional Interaction between Neural Sources.
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DOI：
10.1371/journal.pone.0167351
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Deouell LY
中科院分区：
文献类型：
--
作者：
Gerber EM;Sadeh B;Ward A;Knight RT;Deouell LY
交叉频率耦合（CFC）的分析已成为流行的研究，涉及颅内和头皮脑电图记录在人类。有人认为，在某些情况下，CFC是数学上存在的可能不反映两个不同的但功能耦合的神经源与不同的频率的相互作用。在这里，我们提供了两个经验的例子，从颅内记录CFC可以被证明是由一个周期性的波形，而不是由不同的源之间的功能相互作用的形状驱动。使用模拟，我们还提出了一个广义和现实的情况下，这种耦合可能会出现。这种情况，我们称之为波形相关CFC，出现在尖锐波形（例如，皮层电位）在数据的各个部分中发生，特别是如果它们有节奏地发生。由于波形包含低频和高频分量，只要波形以适当的间隔隔开，这些分量就可以固有地相位对准。我们认为，这种行为的数据，这似乎是目前在各种皮层信号，不能被解释为反映不同的神经源之间的功能调制没有额外的证据。此外，我们表明，即使是低振幅的周期性电位，不能很容易地观察到或控制，是足够的显着CFC发生。
The analysis of cross-frequency coupling (CFC) has become popular in studies involving intracranial and scalp EEG recordings in humans. It has been argued that some cases where CFC is mathematically present may not reflect an interaction of two distinct yet functionally coupled neural sources with different frequencies. Here we provide two empirical examples from intracranial recordings where CFC can be shown to be driven by the shape of a periodic waveform rather than by a functional interaction between distinct sources. Using simulations, we also present a generalized and realistic scenario where such coupling may arise. This scenario, which we term waveform-dependent CFC, arises when sharp waveforms (e.g., cortical potentials) occur throughout parts of the data, in particular if they occur rhythmically. Since the waveforms contain both low- and high-frequency components, these components can be inherently phase-aligned as long as the waveforms are spaced with appropriate intervals. We submit that such behavior of the data, which seems to be present in various cortical signals, cannot be interpreted as reflecting functional modulation between distinct neural sources without additional evidence. In addition, we show that even low amplitude periodic potentials that cannot be readily observed or controlled for, are sufficient for significant CFC to occur.
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