Quantifying and reducing the effect of calibration error on variability of PET/CT standardized uptake value measurements.
Quantifying and reducing the effect of calibration error on variability of PET/CT standardized uptake value measurements.
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DOI：
10.2967/jnumed.110.083865
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Kinahan PE
中科院分区：
文献类型：
--
作者：
Lockhart CM;MacDonald LR;Alessio AM;McDougald WA;Doot RK;Kinahan PE
本研究的目的是测量PET/CT扫描仪的定期校准引入的误差，并尽量减少校准误差对标准化摄取值测量的影响。记录了来自2台PET/CT扫描仪的3.5年和1.8年的全局校准因子，将医生推荐的方案与修改后的方案进行比较，以评估由于操作员影响的程序而导致的误差贡献。使用美国国家标准与技术研究所可追溯来源评价剂量校准器测量值。剂量校准品变异性小于1%，但存在一致偏倚。当质量保证和质量控制程序应用于校准协议时，扫描仪1的全局缩放可变性从6%降低到4%，扫描仪2的全局缩放可变性从11%降低到4%。当使用68 Ge/68 Ga体模进行校准时，两种扫描仪的变异性均降低至约3%。将质量保证和质量控制程序应用于扫描仪校准减少了可变性，但是仍然存在3%-4%的剩余纵向扫描仪可变性。这里提出的程序减少了扫描仪校准的操作员错误的影响，从而最大限度地减少了标准化摄取值测量的纵向变异性。
The purpose of this study was to measure the errors introduced by regular calibration of PET/CT scanners and to minimize the effect of calibration error on standardized uptake value measurements. Global calibration factors from 2 PET/CT scanners were recorded for 3.5 and 1.8 y, comparing manufacturer-recommended protocols with modified protocols to evaluate error contributions due to operator-influenced procedures. Dose calibrator measurements were evaluated using National Institute of Standards and Technology–traceable sources. Dose calibrator variability was less than 1%, although there was a consistent bias. Global scaling variability was reduced from 6% to 4% for scanner 1 and from 11% to 4% for scanner 2 when quality assurance and quality control procedures were applied to the calibration protocol. When calibrations were done using a 68Ge/68Ga phantom, the variability for both scanners was reduced to approximately 3%. Applying quality assurance and quality control procedures to scanner calibration reduces variability, but there is a still a residual longitudinal scanner variability of 3%–4%. The procedures proposed here reduce the impact of operator error on scanner calibration and thereby minimize longitudinal variability in standarized uptake value measurements.
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影响因子：
3.8
作者：
Doot, R. K.;Scheuermann, J. S.;Kinahan, P. E.
通讯作者：
Kinahan, P. E.
影响因子：
9.3
作者：
Boellaard, Ronald
通讯作者：
Boellaard, Ronald
影响因子：
9.3
作者：
Velasquez, Linda M.;Boellaard, Ronald;Galbraith, Susan M.
通讯作者：
Galbraith, Susan M.
DOI：
10.1007/s00259-006-0131-5
发表时间：
2006-07-01
影响因子：
9.1
作者：
Lammertsma, Adriaan A.;Hoekstra, Corneline J.;Hoekstra, Otto S.
通讯作者：
Hoekstra, Otto S.
影响因子：
19.7
作者：
ZASADNY, KR;WAHL, RL
通讯作者：
WAHL, RL