Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity.
Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity.
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DOI：
10.1038/ijo.2017.126
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Franks S
中科院分区：
文献类型：
--
作者：
Couto Alves A;Valcarcel B;Mäkinen VP;Morin-Papunen L;Sebert S;Kangas AJ;Soininen P;Das S;De Iorio M;Coin L;Ala-Korpela M;Järvelin MR;Franks S
多囊卵巢综合征（PCOS）是一种常见的生殖系统疾病，与肥胖、胰岛素抵抗和糖尿病等代谢紊乱有关。在这里，我们调查PCOS妇女代谢谱的变化是否是由肥胖倾向增加驱动的，或者是与睾酮水平增加相关的PCOS的特定特征。我们对PCOS病例（n=145）和对照组（n=687）进行了一项NMR代谢组学关联研究，这些病例嵌套在一个基于人群的出生队列（n=3127）中。受试者在检查时年龄为31岁。主要分析调整了腰围（WC）作为中心性肥胖的替代指标。随后，在预定义的WC分层内比较病例和对照之间的代谢物浓度。在每个分层中，在病例和对照组中分别进行了额外的代谢组学与睾酮水平的关联分析。总的来说，PCOS女性比对照组表现出更多的不良代谢产物。经WC校正和多重检验校正后，极低密度脂蛋白（VLDL）不同亚类中的4种脂质组分与PCOS相关（P<0.002）。在分层分析中，与对照组相比，大WC层（> 98 cm）内的PCOS妇女的高密度脂蛋白（HDL）水平、载脂蛋白A1和白蛋白值显著降低。在PCOS患者中，特氟沙星水平与VLDL和血脂显著相关，而在对照组中则无相关性。较高的睾酮水平，调整WC，与胰岛素水平和HOMA IR的情况下，但不是在控制。我们的研究结果表明，腹部肥胖和高雄激素血症都有助于PCOS的血脂异常和其他代谢特征，这些都可能对PCOS女性的长期健康产生负面影响。
Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels. We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3127). Subjects were 31 years old at examination. The main analyses were adjusted for waist circumference (WC) as a proxy measure of central obesity. Subsequently, metabolite concentrations were compared between cases and controls within pre-defined WC strata. In each stratum, additional metabolomics association analyses with testosterone levels were conducted separately among cases and controls. Overall, women with PCOS showed more adverse metabolite profiles than the controls. Four lipid fractions in different subclasses of very low density lipoprotein (VLDL) were associated with PCOS, after adjusting for WC and correction for multiple testing (P<0.002). In stratified analysis the PCOS women within large WC strata (⩾98 cm) had significantly lower high density lipoprotein (HDL) levels, Apo A1 and albumin values compared with the controls. Testosterone levels were significantly associated with VLDL and serum lipids in PCOS cases with large WC but not in the controls. The higher testosterone levels, adjusted for WC, associated adversely with insulin levels and HOMA IR in cases but not in the controls. Our findings show that both abdominal obesity and hyperandrogenism contribute to the dyslipidaemia and other metabolic traits of PCOS which all may negatively contribute to the long-term health of women with PCOS.
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影响因子：
30.8
作者：
Kettunen, Johannes;Tukiainen, Taru;Sarin, Antti-Pekka;Ortega-Alonso, Alfredo;Tikkanen, Emmi;Lyytikainen, Leo-Pekka;Kangas, Antti J.;Soininen, Pasi;Wuertz, Peter;Silander, Kaisa;Dick, Danielle M.;Rose, Richard J.;Savolainen, Markku J.;Viikari, Jorma;Kahonen, Mika;Lehtimaki, Terho;Pietilainen, Kirsi H.;Inouye, Michael;McCarthy, Mark I.;Jula, Antti;Eriksson, Johan;Raitakari, Olli T.;Salomaa, Veikko;Kaprio, Jaakko;Jarvelin, Marjo-Riitta;Peltonen, Leena;Perola, Markus;Freimer, Nelson B.;Ala-Korpela, Mika;Palotie, Aarno;Ripatti, Samuli
通讯作者：
Ripatti, Samuli
影响因子：
3.6
作者：
Alves, Alexessander C.;Li, Jia V.;Ebbels, Timothy M. D.
通讯作者：
Ebbels, Timothy M. D.
影响因子：
3.2
作者：
Barber, T. M.;McCarthy, M. I.;Franks, S.
通讯作者：
Franks, S.
影响因子：
2.1
作者：
Gao, Xiaoyi;Stamier, Joshua;Martin, Eden R.
通讯作者：
Martin, Eden R.
影响因子：
3.8
作者：
Li, J;Ji, L
通讯作者：
Ji, L