High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas.
High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas.
复制标题
DOI：
10.1007/s11060-014-1376-7
复制
发表时间：
2014-03
影响因子：
3.9
通讯作者：
Bachoo, Robert M.
中科院分区：
文献类型：
--
作者：
Hatanpaa, Kimmo J.;Hu, Tianshen;Vemireddy, Vamsidhara;Foong, Chan;Raisanen, Jack M.;Oliver, Dwight;Hiemenz, Matthew C.;Burns, Dennis K.;White, Charles L., III;Whitworth, L. Anthony;Mickey, Bruce;Stegner, Martha;Habib, Amyn A.;Fink, Karen;Maher, Elizabeth A.;Bachoo, Robert M.
浸润性星形细胞瘤和寡成星形细胞瘤的低至间变性级别（WHO分级II级和III级），尽管与广泛的临床结果相关，但很难根据当前的组织病理学标准进行亚分类和分级。与可以通过1p/19q编码识别的少突胶质细胞瘤和间变性少突胶质细胞瘤和更恶性的胶质母细胞瘤（WHO IV级星形细胞瘤）不同，后者可以仅根据常规苏木精和伊红切片的客观特征进行诊断，II-III级星形细胞瘤和少突星形细胞瘤（A+OA II-III）的亚分类没有这样的客观标准。在这项研究中，我们利用免疫组织化学和组织芯片计算机辅助分析评估了干细胞标记物nestin在成人A+OA II-III （n=50）中的预后和预测价值。此外，在NCI Rembrandt数据库中分析nestin mRNA水平与总生存率的相关性。结果显示，巢蛋白高表达是影响总生存率的一个重要不良预后因素（p=0.0004）。相关性的强度与异柠檬酸脱氢酶1/2 （IDH 1/2）突变状态相当，但与之无关。组织病理学分级和亚分类与结果没有显著相关性，尽管这一发现的解释受到III级肿瘤比II级肿瘤更积极治疗这一事实的限制。这些结果表明，巢蛋白水平和IDH 1/2突变状态是A+OA II-III的重要预后特征，可能比常规的组织病理学变量(如少突胶质成分（星形细胞瘤vs少突星形细胞瘤）和WHO分级（II级vs III级）更有助于治疗计划。
Infiltrating astrocytomas and oligoastrocytomas of low to anaplastic grade (WHO grades II and III), in spite of being associated with a wide range of clinical outcomes, can be difficult to subclassify and grade by the current histopathologic criteria. Unlike oligodendrogliomas and anaplastic oligodendrogliomas that can be identified by the 1p/19q codeletion and the more malignant glioblastomas (WHO grade IV astrocytomas) that can be diagnosed solely based on objective features on routine hematoxylin and eosin sections, no such objective criteria exist for the subclassification of grade II-III astrocytomas and oligoastrocytomas (A+OA II-III). In this study, we evaluated the prognostic and predictive value of the stem cell marker nestin in adult A+OA II-III (n=50) using immunohistochemistry and computer-assisted analysis on tissue microarrays. In addition, the correlation between nestin mRNA level and total survival was analyzed in the NCI Rembrandt database. The results showed that high nestin expression is a strong adverse prognostic factor for total survival (p=0.0004). The strength of the correlation was comparable to but independent of the isocitrate dehydrogenase 1/2 (IDH 1/2) mutation status. Histopathological grading and subclassification did not correlate significantly with outcome, although the interpretation of this finding is limited by the fact that grade III tumors were treated more aggressively than grade II tumors. These results suggest that nestin level and IDH 1/2 mutation status are strong prognostic features in A+OA II-III and possibly more helpful for treatment planning than routine histopathological variables such as oligodendroglial component (astrocytoma vs. oligoastrocytoma) and WHO grade (grade II vs. III).
登录
查看更多内容
影响因子：
5.2
作者：
Madhavan, Subha;Zenklusen, Jean-Claude;Kotliarov, Yuri;Sahni, Himanso;Fine, Howard A.;Buetow, Kenneth
通讯作者：
Buetow, Kenneth
影响因子：
3.6
作者：
Maderna, Ernanuela;Salmaggi, Andrea;Pollo, Bianco
通讯作者：
Pollo, Bianco
Nestin在不同肿瘤中的表达及其与恶性程度的相关性
影响因子：
3.4
作者：
Yang, X. H.;Wu, Q. L.;Xiang, A. P.
通讯作者：
Xiang, A. P.
影响因子：
3.7
作者：
Chen HL;Yuh CH;Wu KK
通讯作者：
Wu KK
影响因子：
12.7
作者：
Hartmann, Christian;Hentschel, Bettina;von Deimling, Andreas
通讯作者：
von Deimling, Andreas