Relation of carotid plaque with natural IgM antibodies in patients with systemic lupus erythematosus.
Relation of carotid plaque with natural IgM antibodies in patients with systemic lupus erythematosus.
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DOI：
10.1016/j.clim.2014.03.017
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Silverman GJ
中科院分区：
文献类型：
--
作者：
Grönwall C;Reynolds H;Kim JK;Buyon J;Goldberg JD;Clancy RM;Silverman GJ
无创性颈动脉测量在估计系统性红斑狼疮（SLE）患者未来心血管（CV）结局方面具有独立价值。磷酸胆碱（PC）表位的天然IgM抗体可以增强抗炎细胞清除并诱导抗炎途径。在此，我们表明，与无斑块的患者相比，在横断面SLE队列中，通过颈动脉超声检测到的亚临床CV疾病与较低水平的抗PC IgM以及较低水平的抗PC IgM/总IgM比率相关（分别为p=0.004和p=0.02）。调整年龄、胆固醇和高血压后，IgM抗PC/总IgM相关性仍然显著。脂联素和可溶性E-选择素在斑块患者中显著升高，统计模型显示，脂联素、可溶性E-选择素和IgM抗PC/总IgM联合检测比单独检测更能预测斑块。这些结果支持IgM天然自身抗体可抑制动脉粥样硬化形成的假设，并证实IgM抗PC水平作为亚临床CV疾病的生物标志物的效用。
Noninvasive carotid measurements have independent value in the estimation of future cardiovascular (CV) outcomes in systemic lupus erythematosus (SLE). Natural IgM-antibodies to phosphorylcholine (PC) epitopes can enhance apoptotic-cell clearance and induce anti-inflammatory pathways. Herein, we show that subclinical CV disease, as detected by carotid ultrasound, in a cross-sectional SLE cohort was associated with lower levels of IgM anti-PC, as well as lower levels of the ratio of IgM anti-PC/total IgM, compared to patients without plaque (p=0.004 and p=0.02, respectively). The IgM anti-PC/total IgM association remained significant after adjusting for age, cholesterol and hypertension. Adiponectin and sE-selectin were significantly elevated in patients with plaque, and statistical models showed that combining adiponectin, sE-selectin and IgM anti-PC/total IgM was better for predicting plaque than either test alone. These results support the hypothesis that IgM-natural autoantibodies may inhibit atherogenesis, and confirms the utility of IgM anti-PC levels as a biomarker for subclinical CV disease.
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与凋亡相关决定因素的IgM抗体募集C1Q并增强凋亡细胞的树突状细胞吞噬作用。
DOI：
10.4049/jimmunol.0804191
发表时间：
2009-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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Silverman GJ
影响因子：
2.6
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27.4
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Carmona L
DOI：
10.1016/j.echo.2007.11.011
发表时间：
2008-02-01
影响因子：
6.5
作者：
Stein, James H.;Korcarz, Claudia E.;Post, Wendy S.
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Post, Wendy S.
DOI：
10.1073/pnas.1211868109
发表时间：
2012-11-27
影响因子：
11.1
作者：
Groenwall, Caroline;Chen, Yifang;Silverman, Gregg J.
通讯作者：
Silverman, Gregg J.