Causative species and serotypes of shigellosis in mainland China: systematic review and meta-analysis.
Causative species and serotypes of shigellosis in mainland China: systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0052515
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Chang Z;Lu S;Chen L;Jin Q;Yang J
志贺氏菌是志贺氏菌病的病原体，是一个主要的全球公共卫生问题，特别是在卫生条件差的发展中国家。全面了解目前志贺菌病的流行菌种和血清型对于疾病预防和疫苗开发至关重要。然而，在过去的十年中，没有关于中国大陆志贺菌病病原种/血清型的现有数据。从PubMed和中国生物医学文献数据库（中文）中检索到2001年1月至2010年12月期间中国大陆志贺菌病流行菌种的相关研究，直至2012年4月。本次综述共纳入131篇合格文章（136项研究）。Meta分析显示，S. flexneri和S. Sonnei的阳性率分别为76.2%（95%CI，73.7%~ 78.5%）和21.3%（95%CI，19.0%~ 23.7%）。分层分析表明，S。flexneri病例和S.近年来，随着中国经济的快速增长，此外，S.在我国东部、北部和东北地区，与全国其他地区相比，这些现象意味着志贺菌的流行种和区域经济状况之间可能存在关联，但是，还存在其他因素，需要进一步调查。此外，两种主要的血清型S。福氏2a和4c分别占沙门氏菌的21.5%（95%CI，16.7%~ 27.4%）和12.9%（95%CI，9.8%~ 16.9%）。福氏杆菌感染的病例。然而，发现这些结果经常是异质的（Q检验的p <0.01）。本文综述了中国大陆志贺菌病的最新病原学研究进展，并强调了加强对志贺菌病的预防和研究的重要性。sonnei和新出现的S.福氏血清型4c。
Shigella, the causative agent of shigellosis, is a major global public health concern, particularly in developing countries with poor sanitation. A comprehensive and current understanding of the prevalent species and serotypes of shigellosis is essential for both disease prevention and vaccine development. However, no current data are available on the causative species/serotypes of shigellosis in mainland China during the past decade. Relevant studies addressing the prevalent species of shigellosis in mainland China from January 2001 to December 2010 were identified from PubMed and the Chinese BioMedical Literature Database (in Chinese) until April 2012. A total of 131 eligible articles (136 studies) were included in this review. Meta-analyses showed that the prevalences of S. flexneri and S. sonnei were 76.2% (95% CI, 73.7%–78.5%) and 21.3% (95% CI, 19.0%–23.7%), respectively. Stratified analyses indicated a decrease in the prevalence of S. flexneri cases and an increase in the prevalence of S. sonnei cases concurrent with the rapid economic growth experienced by China in recent years. Moreover, significantly higher rates of S. sonnei were observed in the East, North and Northeast regions of China, as compared to the rest of the country. These phenomena imply the possible association between the prevalent species of Shigella and regional economic status; however, additional factors also exist and require further investigations. Moreover, the two major serotypes S. flexneri 2a and 4c accounted for 21.5% (95% CI, 16.7%–27.4%) and 12.9% (95% CI 9.8%–16.9%) of S. flexneri infections, respectively, in the past decade. However, these results were found to be frequently heterogeneous (p for Q tests <0.01). This study provides an updated review of the causative agents of shigellosis in mainland China and focuses on the importance of strengthening prevention and research efforts on S. sonnei and the newly emerged S. flexneri serotype 4c.
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志贺氏菌种类的基因组动力学和多样性，杆菌痢疾的病因学剂。
影响因子：
14.9
作者：
Yang, F;Yang, J;Zhang, XB;Chen, LH;Jiang, Y;Yan, YL;Tang, XD;Wang, J;Xiong, ZH;Dong, J;Xue, Y;Zhu, YF;Xu, XY;Sun, LL;Chen, SX;Nie, H;Peng, JP;Xu, JG;Wang, Y;Yuan, ZH;Wen, YM;Yao, ZJ;Shen, Y;Qiang, BQ;Hou, YD;Yu, J;Jin, Q
通讯作者：
Jin, Q
影响因子：
9.4
作者：
PRYAMUKHINA, NS;KHOMENKO, NA
通讯作者：
KHOMENKO, NA
DOI：
10.1098/rspb.2005.3108
发表时间：
2005-08-07
影响因子：
4.7
作者：
van Boven, M;Mooi, FR;Kretzschmar, M
通讯作者：
Kretzschmar, M
影响因子：
11.8
作者：
Bardhan P;Faruque AS;Naheed A;Sack DA
通讯作者：
Sack DA
影响因子：
15.8
作者：
von Seidlein L;Kim DR;Ali M;Lee H;Wang X;Thiem VD;Canh DG;Chaicumpa W;Agtini MD;Hossain A;Bhutta ZA;Mason C;Sethabutr O;Talukder K;Nair GB;Deen JL;Kotloff K;Clemens J
通讯作者：
Clemens J