Experimental rabies vaccines for humans.
Experimental rabies vaccines for humans.
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DOI：
10.1586/erv.10.105
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发表时间：
2010-10
影响因子：
6.2
通讯作者：
McGettigan JP
中科院分区：
文献类型：
--
作者：
McGettigan JP
狂犬病仍然是全球公共卫生威胁，每年造成5.5万多人死亡。狂犬病对儿童的影响尤为严重，因此，由于寿命损失，狂犬病在最重要的传染病中排名第七。人类狂犬病的预防是通过控制家畜和野生动物的狂犬病来实现的，包括使用疫苗接种计划。人类狂犬病疫苗的效用受到高昂费用、复杂的疫苗接种方案和缺乏遵守的阻碍，特别是在人类狂犬病感染流行的非洲和亚洲地区。单剂疫苗将极大地有利于抗击这一全球健康威胁的努力。然而，基于当前灭活疫苗的单剂量疫苗似乎不可行，需要其他方法。自从40多年前研制出现代人类狂犬病疫苗以来，技术已经取得了进步。此外，我们对影响疫苗接种结果的免疫学原理的理解也有所增加。本文描述了灭活狂犬病毒疫苗的现状，以及利用反向遗传学技术开发复制缺陷或单循环活狂犬病毒载体作为人类单剂量狂犬病疫苗的最新进展。
Rabies remains a global public health threat that kills more than 55,000 people per year. Rabies disproportionately affects children and, therefore, is ranked the seventh most important infectious disease due to years lost. Prevention of human rabies is accomplished by controlling rabies in domestic and wild animals, including the use of vaccination programs. The usefulness of human rabies vaccines is hampered by high cost, complicated vaccination regimens and lack of compliance, especially in areas of Africa and Asia where human rabies infections are endemic. A single-dose vaccine would greatly benefit efforts to combat this global health threat. However, a single-dose vaccine based on current inactivated vaccines does not appear feasible and other approaches are needed. Technology has advanced since modern human rabies vaccines were developed over 40 years ago. In addition, our understanding of immunological principles that influence the outcome of vaccination has increased. This article describes the current status of inactivated rabies virus vaccines and recent developments arising from the use of reverse genetics technologies designed to develop replication-deficient or single-cycle live rabies virus-based vectors for use as a single-dose rabies vaccine for humans.
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影响因子：
5.1
作者：
Kamoltham, Thavatchai;Thinyounyong, Wirawan;Malerczyk, Claudius
通讯作者：
Malerczyk, Claudius
影响因子：
5.4
作者：
Brzózka, K;Finke, S;Conzelmann, KK
通讯作者：
Conzelmann, KK
影响因子：
20.3
作者：
Blanchard-Rohner, Geraldine;Pulickal, Anoop S.;Pollard, Andrew J.
通讯作者：
Pollard, Andrew J.
影响因子：
3.8
作者：
Ertl HC
通讯作者：
Ertl HC
影响因子：
5.5
作者：
Faul, Elizabeth J.;Aye, Pyone P.;Schnell, Matthias J.
通讯作者：
Schnell, Matthias J.