Genome dynamics in major bacterial pathogens.
Genome dynamics in major bacterial pathogens.
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DOI：
10.1111/j.1574-6976.2009.00173.x
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发表时间：
2009-05
影响因子：
11.3
通讯作者：
Tønjum T
中科院分区：
文献类型：
--
作者：
Ambur OH;Davidsen T;Frye SA;Balasingham SV;Lagesen K;Rognes T;Tønjum T
病原菌在恶劣的环境中不断遇到多种形式的应激，导致DNA损伤。随着基因组序列提供了对生物学的新见解，编码蛋白质的基因内容的阐明为理解与栖息地和生态位相关的微生物生活方式提供了线索。空肠弯曲杆菌、流感嗜血杆菌、幽门螺杆菌、结核分枝杆菌、致病性奈瑟氏菌、肺炎链球菌、化脓性链球菌和金黄色葡萄球菌是全球范围内危害人类健康的主要病原菌。为了确定在所研究的致病菌基因组中是否存在所选基因的同源基因，建立了一种同源基因聚类算法。根据选定的病原菌中各种功能的已知基因及其同源基因，对不同类型基因的存在进行了概述。在此背景下，我们专注于在这些特定病原体中实现基因组动态的选定过程，即DNA修复、重组和水平基因转移。近年来，对参与DNA代谢的酶的确切分子功能及其在维持细菌基因组完整性方面的重要性的了解也表明了这些酶作为治疗干预目标的未来作用。
Pathogenic bacteria continuously encounter multiple forms of stress in their hostile environments, which leads to DNA damage. With the new insight into biology offered by genome sequences, the elucidation of the gene content encoding proteins provides clues toward understanding the microbial lifestyle related to habitat and niche. Campylobacter jejuni, Haemophilus influenzae, Helicobacter pylori, Mycobacterium tuberculosis, the pathogenic Neisseria, Streptococcus pneumoniae, Streptococcus pyogenes and Staphylococcus aureus are major human pathogens causing detrimental morbidity and mortality at a global scale. An algorithm for the clustering of orthologs was established in order to identify whether orthologs of selected genes were present or absent in the genomes of the pathogenic bacteria under study. Based on the known genes for the various functions and their orthologs in selected pathogenic bacteria, an overview of the presence of the different types of genes was created. In this context, we focus on selected processes enabling genome dynamics in these particular pathogens, namely DNA repair, recombination and horizontal gene transfer. An understanding of the precise molecular functions of the enzymes participating in DNA metabolism and their importance in the maintenance of bacterial genome integrity has also, in recent years, indicated a future role for these enzymes as targets for therapeutic intervention.
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影响因子：
64.5
作者：
Boshoff, HIM;Reed, MB;Mizrahi, V
通讯作者：
Mizrahi, V
影响因子：
7
作者：
Alm, EJ;Huang, KH;Arkin, AP
通讯作者：
Arkin, AP
影响因子：
64.8
作者：
Alm, RA;Ling, LSL;Trost, TJ
通讯作者：
Trost, TJ
影响因子：
3.6
作者：
Amundsen SK;Fero J;Hansen LM;Cromie GA;Solnick JV;Smith GR;Salama NR
通讯作者：
Salama NR
DOI：
10.1099/mic.0.2006/004200-0
发表时间：
2007-05
期刊：
Microbiology (Reading, England)
影响因子：
--
作者：
Assalkhou R;Balasingham S;Collins RF;Frye SA;Davidsen T;Benam AV;Bjørås M;Derrick JP;Tønjum T
通讯作者：
Tønjum T