Surface-based vertexwise analysis of morphometry and microstructural integrity for white matter tracts in diffusion tensor imaging: With application to the corpus callosum in Alzheimer's disease.
Surface-based vertexwise analysis of morphometry and microstructural integrity for white matter tracts in diffusion tensor imaging: With application to the corpus callosum in Alzheimer's disease.
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扩散张量成像中白质束形态测量和微结构完整性的基于表面的顶点分析：应用于阿尔茨海默病的胼胝体
DOI：
10.1002/hbm.23491
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发表时间：
2017-04
影响因子：
4.8
通讯作者：
Miller MI
中科院分区：
文献类型：
--
作者：
Tang X;Qin Y;Zhu W;Miller MI
在本文中，我们提出了一个统一的统计管道分析的白色物质（WM）束形态和显微结构的完整性，全球和本地在同一WM道，从扩散张量成像（DTI）。通过体积测量和局部顶点表面积对形态学进行全局量化。同时，微观结构的完整性是量化的全球范围内的平均分数各向异性（FA）和跟踪值的特定WM道和局部的FA和跟踪值定义在其边界表面的每个顶点。所提出的流水线包括四个步骤：1）在多对比度多图谱框架中完全自动分割WM束; 2）生成感兴趣WM束的光滑表面表示; 3）共同模板表面生成，在其上定义局部形态测量和显微结构统计，并且可以进行各种统计分析; 4）多重比较校正，确定统计分析结果的显著性。本文详细描述的是，该管道已应用于阿尔茨海默病（AD）中的胼胝体，当与正常老龄化人群相比时，在AD患者中检测到全局和局部的FA值显著降低和痕量值增加。胼胝体在两个半球的细分显示，AD病理主要影响胼胝体的身体和压部。验证分析和两个多重比较校正策略。
In this paper, we present a unified statistical pipeline for analyzing the white matter (WM) tracts morphometry and microstructural integrity, both globally and locally within the same WM tract, from diffusion tensor imaging (DTI). Morphometry is quantified globally by the volumetric measurement and locally by the vertexwise surface areas. Meanwhile, microstructural integrity is quantified globally by the mean fractional anisotropy (FA) and trace values within the specific WM tract and locally by the FA and trace values defined at each vertex of its bounding surface. The proposed pipeline consists of four steps: 1) fully automated segmentation of WM tracts in a multi-contrast multi-atlas framework; 2) generation of the smooth surface representations for the WM tracts of interest; 3) common template surface generation on which the localized morphometric and microstructural statistics are defined and a variety of statistical analyses can be conducted; 4) multiple comparison correction to determine the significance of the statistical analysis results. Detailed herein, this pipeline has been applied to the corpus callosum in Alzheimer’s disease (AD) with significantly decreased FA values and increased trace values, both globally and locally, being detected in patients with AD when compared to normal aging populations. A subdivision of the corpus callosum in both hemispheres revealed that the AD pathology primarily affects the body and splenium of the corpus callosum. Validation analyses and two multiple comparison correction strategies are provided.
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影响因子：
5.7
作者：
Jeon, Tina;Mishra, Virendra;Uh, Jinsoo;Weiner, Myron;Hatanpaa, Kimmo J.;White, Charles L., III;Zhao, Yan D.;Lu, Hanzhang;Diaz-Arrastia, Ramon;Huang, Hao
通讯作者：
Huang, Hao
影响因子：
3.3
作者：
Baron, Corey A.;Beaulieu, Christian
通讯作者：
Beaulieu, Christian
DOI：
10.1111/j.1532-5415.1996.tb03736.x
发表时间：
1996-07-01
影响因子：
6.3
作者：
Janowsky, JS;Kaye, JA;Carper, RA
通讯作者：
Carper, RA
影响因子：
3.1
作者：
Ardekani, Babak A.;Bachman, Alvin H.;Figarsky, Khadija;Sidtis, John J.
通讯作者：
Sidtis, John J.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y