Corpus callosum shape changes in early Alzheimer's disease: an MRI study using the OASIS brain database.
Corpus callosum shape changes in early Alzheimer's disease: an MRI study using the OASIS brain database.
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DOI：
10.1007/s00429-013-0503-0
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发表时间：
2014-01
影响因子：
3.1
通讯作者：
Sidtis, John J.
中科院分区：
文献类型：
--
作者：
Ardekani, Babak A.;Bachman, Alvin H.;Figarsky, Khadija;Sidtis, John J.
胼胝体（CC）是连接左右脑半球的最大纤维束。这是一个广泛检查各种病理适应症的地区，包括阿尔茨海默病（AD）。几乎所有关于AD中CC的研究都关注其大小，特别是其中矢状面横截面积（CCA）。在这项研究中，我们发现在早期AD中，CC形状（以其圆度（CIR）为特征）可能比其大小受到更深刻的影响。MRI扫描（n = 196）从公开获取的影像研究系列数据库中获得。采用一种新颖的算法对大脑正中矢状面CC横截区域进行自动分割。比较了98例正常对照（NC）、70例极轻度AD （AD- vm）和28例轻度AD （AD- m）患者的CCA和CIR。控制年龄和颅内容量的协方差统计分析显示，AD-VM组相对于NC组CIR和CCA均显著降低（CIR: p = 0.004; CCA: p = 0.005）。然而，AD-M组和AD-VM组之间只有CIR有显著差异（p = 0.006），前者较小。AD-M组和AD-VM组的CCA无显著性差异。结果表明，CC形状可能是监测AD进展的一个比其大小更敏感的标志物。为了便于独立分析，本研究中使用的CC分割以及CCA和CIR数据已经公开（http://www.nitrc.org/projects/art）。
The corpus callosum (CC) is the largest fiber bundle connecting the left and right cerebral hemispheres. It has been a region examined extensively for indications of various pathologies, including Alzheimer’s disease (AD). Almost all previous studies of the CC in AD have been concerned with its size, particularly its mid-sagittal cross-sectional area (CCA). In this study, we show that the CC shape, characterized by its circularity (CIR), may be affected more profoundly than its size in early AD. MRI scans (n = 196) were obtained from the publicly available Open Access Series of Imaging Studies database. The CC cross-sectional region on the mid-sagittal section of the brain was automatically segmented using a novel algorithm. The CCA and CIR were compared in 98 normal controls (NC) subjects, 70 patients with very mild AD (AD-VM), and 28 patients with mild AD (AD-M). Statistical analysis of covariance controlling for age and intracranial capacity showed that both the CIR and the CCA were significantly reduced in the AD-VM group relative to the NC group (CIR: p = 0.004; CCA: p = 0.005). However, only the CIR was significantly different between the AD-M and AD-VM groups (p = 0.006) being smaller in the former. The CCA was not significantly different between the AD-M and AD-VM groups. The results suggest that CC shape may be a more sensitive marker than its size for monitoring the progression of AD. In order to facilitate independent analyses, the CC segmentations and the CCA and CIR data used in this study have been made publicly available (http://www.nitrc.org/projects/art).
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DOI：
10.1111/j.1532-5415.1996.tb03736.x
发表时间：
1996-07-01
影响因子：
6.3
作者：
Janowsky, JS;Kaye, JA;Carper, RA
通讯作者：
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影响因子：
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作者：
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DOI：
10.1017/s1355617708080533
发表时间：
2008-05-01
影响因子：
2.6
作者：
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通讯作者：
Breitner, John C. S.
影响因子：
4.5
作者：
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Siever, LJ
影响因子：
3.5
作者：
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通讯作者：
Kennedy DN