Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury.
Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury.
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DOI：
10.3390/nu5041253
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发表时间：
2013-04-17
期刊：
影响因子：
5.9
通讯作者：
Weaver LK
中科院分区：
文献类型：
--
作者：
Barker T;Henriksen VT;Martins TB;Hill HR;Kjeldsberg CR;Schneider ED;Dixon BM;Weaver LK
本研究的主要目的是确定血清 25-羟基维生素 D (25(OH)D) 浓度是否可以预测剧烈运动后的肌肉无力。我们假设运动前血清 25(OH)D 浓度与运动引起的肌肉无力呈负相关。十四名从事娱乐活动的成年人参与了这项研究。每个受试者随机分配一条腿作为对照。另一条腿进行了剧烈的锻炼。在剧烈运动之前和之后测量单腿峰值等长力和血液 25(OH)D、天冬氨酸和丙氨酸转氨酶、白蛋白、干扰素 (IFN)-γ 和白介素-4。运动后，血清 25(OH)D 浓度立即升高 (p < 0.05)，但在几分钟内随后下降 (p < 0.05)。循环白蛋白增加预测 (p < 0.005) 血清 25(OH)D 增加，而 IFN-γ 增加预测 (p < 0.001) 血清 25(OH)D 减少。运动方案结束后，与对照腿相比，运动腿的肌肉无力持续存在（p < 0.05）（p < 0.05）。血清 25(OH)D 浓度反向预测 (p < 0.05) 运动后立即和几天（即 48 小时和 72 小时）的肌肉无力（即对照腿与运动腿峰值等长力），表明运动引起的肌肉无力随着运动前血清 25(OH)D 的增加而减弱。根据这些数据，我们得出结论，运动前血清 25(OH)D 浓度可能会影响剧烈运动后骨骼肌力量的恢复。
The primary purpose of this study was to identify if serum 25-hydroxyvitamin D (25(OH)D) concentrations predict muscular weakness after intense exercise. We hypothesized that pre-exercise serum 25(OH)D concentrations inversely predict exercise-induced muscular weakness. Fourteen recreationally active adults participated in this study. Each subject had one leg randomly assigned as a control. The other leg performed an intense exercise protocol. Single-leg peak isometric force and blood 25(OH)D, aspartate and alanine aminotransferases, albumin, interferon (IFN)-γ, and interleukin-4 were measured prior to and following intense exercise. Following exercise, serum 25(OH)D concentrations increased (p < 0.05) immediately, but within minutes, subsequently decreased (p < 0.05). Circulating albumin increases predicted (p < 0.005) serum 25(OH)D increases, while IFN-γ increases predicted (p < 0.001) serum 25(OH)D decreases. Muscular weakness persisted within the exercise leg (p < 0.05) and compared to the control leg (p < 0.05) after the exercise protocol. Serum 25(OH)D concentrations inversely predicted (p < 0.05) muscular weakness (i.e., control leg vs. exercise leg peak isometric force) immediately and days (i.e., 48-h and 72-h) after exercise, suggesting the attenuation of exercise-induced muscular weakness with increasing serum 25(OH)D prior to exercise. Based on these data, we conclude that pre-exercise serum 25(OH)D concentrations could influence the recovery of skeletal muscle strength after an acute bout of intense exercise.
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影响因子：
3
作者：
Barker, Tyler;Martins, Thomas B.;Weaver, Lindell K.
通讯作者：
Weaver, Lindell K.
影响因子：
15.9
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通讯作者：
HADDAD, JG
影响因子：
4.5
作者：
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通讯作者：
Weaver, Lindell K.
影响因子：
4
作者：
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通讯作者：
Boland, Ricardo L.
影响因子：
3.8
作者：
Barker, Tyler;Martins, Thomas B.;Hill, Harry R.
通讯作者：
Hill, Harry R.