Image-derived input function from cardiac gated maximum a posteriori reconstructed PET images in mice.
Image-derived input function from cardiac gated maximum a posteriori reconstructed PET images in mice.
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DOI：
10.1007/s11307-010-0347-4
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发表时间：
2011-04
影响因子：
3.1
通讯作者：
Kundu, Bijoy K.
中科院分区：
文献类型：
--
作者：
Locke, Landon W.;Berr, Stuart S.;Kundu, Bijoy K.
为了确定是否可以从使用有序子集期望最大化-最大后验概率(OSEM-MAP)重建的心脏门控PET图像中测量准确的图像衍生输入函数(IDIF)，而无需进一步校正。对5只C57/BL6小鼠进行了基于CT衰减校正的OSEM-MAP心脏门控PET图像重建，测量了来自左心室(LV)的IDIF。使用Bland-Altman分析对IDIF的准确性进行了测试。经配对t检验，图像测得的血液放射性浓缩值与后两个时间点的血样放射性浓缩值无显著差异(P=0.97)。Bland-Altman分析显示，−为0.06uCi/ml(1%)。使用动力学分析，基于IDIF的平均心肌FDG摄取速率常数与文献报道的基于物理血样的值相当。可以非侵入性地获得准确的IDIF。虽然重建时间增加了，但对于来自门控、OSEM-MAP具有衰减校正的重建图像的IDIF来说，不需要进一步的溢出校正。
To determine if accurate image-derived input functions (IDIF) can be measured from cardiac gated PET images reconstructed using ordered subset expectation maximization – maximum a posteriori (OSEM-MAP) without further correction. IDIFs from the left ventricle (LV) were measured from cardiac gated PET images reconstructed using OSEM-MAP with CT-based attenuation correction for 5 C57/BL6 mice. The accuracy of the IDIF was tested against blood samples using Bland-Altman analysis. Image-derived blood radioactivity concentration values were not significantly different from sampled blood values at two late time points as determined by a paired t-test (P=0.97). Bland-Altman analysis revealed a mean difference of −0.06 µCi/ml (1%). Using kinetics analysis, the mean myocardial FDG uptake rate constant based on the IDIF was comparable to values reported in the literature based on physical blood sampling. Accurate IDIFs can be obtained non-invasively. Although reconstruction times are increased, no further spillover corrections are necessary for IDIFs derived from gated, OSEM-MAP reconstructed images with attenuation correction.
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影响因子：
3.1
作者：
Shoghi, Kooresh I.;Welch, Michael J.
通讯作者：
Welch, Michael J.
影响因子：
9.3
作者：
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通讯作者：
Huang, Sung-Cheng
影响因子：
9.3
作者：
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通讯作者：
Muzic, Raymond F., Jr.
影响因子：
3.5
作者：
Qi, JY;Leahy, RM;Farquhar, TH
通讯作者：
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影响因子：
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作者：
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通讯作者：
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