Interactome networks and human disease.

Interactome networks and human disease.
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DOI:
10.1016/j.cell.2011.02.016
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发表时间:
2011-03-18
期刊:
影响因子:
64.5
通讯作者:
Barabási AL
Barabási AL
中科院分区:
生物学1区
文献类型:
--
作者:
Vidal M;Cusick ME;Barabási AL

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Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
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