Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep.

Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep.
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神经振荡表明全身麻醉和镇静状态在神经生理学上与睡眠不同。

DOI:
10.1016/j.conb.2017.04.011
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发表时间:
2017-06
影响因子:
5.7
通讯作者:
Brown EN
Brown EN
中科院分区:
医学2区
文献类型:
--
作者:
Akeju O;Brown EN

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全身麻醉是一种人为的神经生理状态,包括无意识、遗忘、镇痛和沿着不动以及维持生理稳定。越来越多的证据表明,麻醉诱导的神经振荡是麻醉作用的主要机制。每种麻醉药物类别产生不同的振荡动力学,这可能与药物作用的回路机制有关。睡眠是一种自然发生的觉醒减少的状态,对正常健康至关重要。生理测量(眼电图、肌电图)和神经振荡(脑电图)动力学被用于经验性地将睡眠表征为快速眼动睡眠和非快速眼动睡眠的三个阶段。在这篇综述中,我们从神经振荡的角度讨论了麻醉和睡眠引起的改变状态之间的差异。
General anesthesia is a man-made neurophysiological state comprised of unconsciousness, amnesia, analgesia, and immobility along with maintenance of physiological stability. Growing evidence suggests that anesthetic-induced neural oscillations are a primary mechanism of anesthetic action. Each anesthetic drug class produces distinct oscillatory dynamics that can be related to the circuit mechanisms of drug action. Sleep is a naturally occurring state of decreased arousal that is essential for normal health. Physiological measurements (electrooculogram, electromyogram) and neural oscillatory (electroencephalogram) dynamics are used to empirically characterize sleep into rapid eye movement sleep and the three stages of non-rapid eye movement sleep. In this review, we discuss the differences between anesthesia- and sleep-induced altered states from the perspective of neural oscillations.
DOI: 10.5665/sleep.1112
发表时间: 2011-07-01
期刊: SLEEP
影响因子: 5.6
作者:
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