Ethanol-induced conditioned partner preference in female mice.
Ethanol-induced conditioned partner preference in female mice.
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DOI：
10.1016/j.bbr.2013.01.021
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发表时间：
2013-04-15
影响因子：
2.7
通讯作者：
Rice, Rachel
中科院分区：
文献类型：
--
作者：
Wood, Ruth I.;Rice, Rachel
饮酒行为和社会背景紧密交织在一起。同伴关系可以促进饮酒。相反，酒精促进了社会互动。本研究测试了雌性小鼠对乙醇诱导的条件性伴侣偏好。去卵巢(OVX)C57BL/6雌性慢性雌激素替代(OVX+E)雌性大鼠接受生理盐水或乙醇(1、2或4g/kg)ip，每组配对4次，每次30min，每组1只。试验雌鼠与生理盐水后的CS−刺激雌鼠配对，并与乙醇后的CS+雌鼠配对。配对后，我们在10‘测试中测量了测试雌性与CS+和CS−雌性的接近程度。在第二项研究中，研究人员测试了去势和去势+雌鼠对2.5g/kg乙醇的条件性伴侣偏好(CS+vs CS−)。在不同的小鼠组中，测试和刺激雌性小鼠(IS+)在配对过程中都接受了酒精，以确定测试小鼠是否对另一只醉酒小鼠产生条件性伴侣偏好。OVX+E试验雌鼠对2g/kg乙醇反应表现出对CS+雌鼠的条件性伴侣偏爱(对CS+的偏爱分数变化：+86.6±30.0s/10min)，但在0、1或4g/kg乙醇时不表现出条件性伴偏好。在2.5g/kg乙醇浓度下，OVX+E雌鼠表现出对IS+(+63.6±24.0秒)或CS+雌鼠(+93.8±27.1秒)的条件性伴侣偏好。去势试验雌鼠仅对IS+雌鼠表现出乙醇诱导的条件性伴侣偏爱(+153.8±32.0秒)。这些数据表明，乙醇促进了雌性小鼠的社会偏好，而雌二醇则增强了这一效果。
Drinking behavior and social context are intimately intertwined. Peer relations can promote drinking. Conversely, alcohol promotes social interaction. The present study tested female mice for ethanol-induced conditioned partner preference. Ovariectomized (OVX) C57Bl/6 females with chronic estradiol replacement (OVX+E) received saline or ethanol (1, 2 or 4 g/kg) ip and were paired 4x for 30 min each with 1 of 2 stimulus females. The test female was paired with the CS− stimulus female following saline, and was paired with the CS+ female following ethanol. After pairing, we measured proximity of the test female to the CS+ and CS− females in a 10′ test. In a second study, OVX and OVX+E females were tested for conditioned partner preference (CS+ vs CS−) in response to 2.5 g/kg ethanol. In separate groups of mice, both test and stimulus females (IS+) received ethanol during pairing to determine if test mice develop conditioned partner preference for another intoxicated mouse. OVX+E test females showed conditioned partner preference for the CS+ female in response to ethanol at 2 g/kg (change in preference score for CS+: +86.6±30.0 sec/10 min), but not at 0, 1 or 4 g/kg. At 2.5 g/kg ethanol, OVX+E females developed conditioned partner preference for either IS+ (+63.6±24.0 sec) or CS+ females (+93.8±27.1 sec). OVX test females demonstrated ethanol-induced conditioned partner preference only for the IS+ female (+153.8±32.0 sec). These data demonstrate that ethanol promotes social preference in female mice, and that estradiol enhances this effect.
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