Liver fibrosis indices associated with substantial hematoma expansion in Chinese patients with primary intracerebral hemorrhage.
Liver fibrosis indices associated with substantial hematoma expansion in Chinese patients with primary intracerebral hemorrhage.
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中国原发性脑出血患者肝纤维化指数与血肿严重扩张相关
DOI：
10.1186/s12883-021-02494-0
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发表时间：
2021-12-09
期刊：
影响因子：
2.6
通讯作者：
Wang D
中科院分区：
文献类型：
--
作者：
Wang H;Wu J;Yang X;Liu J;Tao W;Hao Z;Wu B;Liu M;Zhang S;Wang D
肝纤维化是否与脑出血（ICH）后大量血肿扩大（HE）的风险增加有关仍不确定。我们评估了中国原发性脑出血人群中各种肝纤维化指标与实质性HE之间的相关性。连续入组2015年1月至2018年6月期间在发病24 h内入住华西医院的原发性ICH患者。计算6项肝纤维化指标，包括天冬氨酸转氨酶（AST）-血小板比值指数（APRI）、AST/丙氨酸转氨酶比值-血小板比值指数（AARPRI）、纤维化-4（FIB-4）、改良纤维化-4（mFIB-4）、纤维化商（FibroQ）和Forns指数。实质性HE定义为ICH体积较基线增加超过33%或6 mL。使用二元逻辑回归分析每个纤维化指数与实质性HE的关联。在入组的436例患者中，约85%的患者在标准肝脏测定和凝血参数方面显示基本正常的结果。115例（26.4%）患者发生实质性HE。校正后，AARPRI（OR 1.26，95% CI 1.00-1.57）和FIB-4（OR 1.15，95% CI 1.02-1.30）分别与ICH患者发病24 h内的实质性HE独立相关。在发病6小时内的ICH患者中，以下各项指标均与严重HE独立相关：Apri（OR 2.64，95% CI 1.30- 5.36），AARPRI（OR 1.55，95% CI 1.09-2.21），FIB-4（OR 1.35，95% CI 1.08-1.68）、mFIB-4（OR 1.09，95% CI 1.01-1.18）、FibroQ（OR 1.08，95% CI 1.00-1.16）和Forns指数（OR 1.37，95% CI 1.10-1.69）。肝纤维化指标与中国原发性ICH患者发生实质性HE的高风险独立相关，这表明可以在此类患者中常规评估亚临床肝纤维化，以识别实质性HE的高风险患者。在线版本包含补充材料，可通过10.1186/s12883-021-02494-0获得。
Whether liver fibrosis is associated with increased risk for substantial hematoma expansion (HE) after intracerebral hemorrhage (ICH) is still uncertain. We evaluated the association between various liver fibrosis indices and substantial HE in a Chinese population with primary ICH. Primary ICH patients admitted to West China Hospital within 24 h of onset between January 2015 and June 2018 were consecutively enrolled. Six liver fibrosis indices were calculated, including aspartate aminotransferase (AST)-platelet ratio index (APRI), AST/alanine aminotransferase ratio-platelet ratio index (AARPRI), fibrosis-4 (FIB-4), modified fibrosis-4 (mFIB-4), fibrosis quotient (FibroQ) and Forns index. Substantial HE was defined as an increase of more than 33% or 6 mL from baseline ICH volume. The association of each fibrosis index with substantial HE was analyzed using binary logistic regression. Of 436 patients enrolled, about 85% showed largely normal results on standard hepatic assays and coagulation parameters. Substantial HE occurred in 115 (26.4%) patients. After adjustment, AARPRI (OR 1.26, 95% CI 1.00-1.57) and FIB-4 (OR 1.15, 95% CI 1.02-1.30) were independently associated with substantial HE in ICH patients within 24 h of onset, respectively. In ICH patients within 6 h of onset, each of the following indices was independently associated with substantial HE: APRI (OR 2.64, 95% CI 1.30-5,36), AARPRI (OR 1.55, 95% CI 1.09-2.21), FIB-4 (OR 1.35, 95% CI 1.08-1.68), mFIB-4 (OR 1.09, 95% CI 1.01-1.18), FibroQ (OR 1.08, 95% CI 1.00-1.16) and Forns index (OR 1.37, 95% CI 1.10-1.69). Liver fibrosis indices are independently associated with higher risk of substantial HE in Chinese patients with primary ICH, which suggesting that subclinical liver fibrosis could be routinely assessed in such patients to identify those at high risk of substantial HE. The online version contains supplementary material available at 10.1186/s12883-021-02494-0.
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影响因子：
2.5
作者：
Nallagangula KS;Nagaraj SK;Venkataswamy L;Chandrappa M
通讯作者：
Chandrappa M
影响因子：
2.9
作者：
Baik, Minyoul;Kim, Seung Up;Kim, Young Dae
通讯作者：
Kim, Young Dae
影响因子：
158.5
作者：
Mayer, Stephan A.;Brun, Nikolai C.;Steiner, Thorsten
通讯作者：
Steiner, Thorsten
影响因子：
5.3
作者：
Kim, Seung Up;Song, Dongbeom;Kim, Young Dae
通讯作者：
Kim, Young Dae
DOI：
10.3390/diagnostics11010098
发表时间：
2021-01-09
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Ballestri S;Mantovani A;Baldelli E;Lugari S;Maurantonio M;Nascimbeni F;Marrazzo A;Romagnoli D;Targher G;Lonardo A
通讯作者：
Lonardo A