Assessment of potential selection bias in neuroimaging studies of postoperative delirium and cognitive decline: lessons from the SAGES study.
Assessment of potential selection bias in neuroimaging studies of postoperative delirium and cognitive decline: lessons from the SAGES study.
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DOI：
10.1007/s11682-022-00644-7
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发表时间：
2022-08
影响因子：
3.2
通讯作者：
Jones, Richard N.
中科院分区：
文献类型：
--
作者：
Cavallari, Michele;Fong, Tamara G.;Touroutoglou, Alexandra;Dickerson, Bradford C.;Schmitt, Eva;Travison, Thomas G.;Marcantonio, Edward R.;Ngo, Long H.;Libermann, Towia;Pascual-Leone, Alvaro;Shafi, Mouhsin M.;Inouye, Sharon K.;Jones, Richard N.
由于成本和参与者的负担，神经成像研究通常在相对较小的自愿参与者样本中进行。这可能会导致选择偏差。重要的是要确定参与神经影像研究的相关因素，并了解它们对结果测量的影响。我们调查了560名老年外科患者(≥70岁)术后精神障碍对长期(超过48个月)认知功能下降的影响，包括嵌套磁共振队列。我们观察到，精神错乱对认知功能衰退的影响与MRI的参与程度不同。尽管由于偶然性精神障碍导致的认知衰退的总体差异并不大于可能的预期(p=0.21)，但在非核磁共振组中，精神错乱与长时相关联(−0.063，95%CI−0.094至−0.032，p<；.001)；而在核磁共振组中，精神错乱的影响较小且不显著(−0.023，95%CI−0.076，0.030，p=.39)。由于这限制了我们使用MRI数据研究精神错乱和认知衰退的神经相关性的能力，我们试图使用参与MRI的反向概率加权来缓解观察到的差异。手术入路不成功，斜面精神错乱的影响差异基本不变。没有证据表明MRI亚组经历了与MRI非参与者相比在严重程度上不同的神志不清。我们不能将观察到的差异归因于基于测量因素的选择偏见。它可能反映了由于MRI子样本较小或来自不可测量因素的选择偏差而导致的电源问题。
Due to cost and participant burden, neuroimaging studies are often performed in relatively small samples of voluntary participants. This may lead to selection bias. It is important to identify factors associated with participation in neuroimaging studies and understand their effect on outcome measures. We investigated the effect of postoperative delirium on long-term (over 48 months) cognitive decline (LTCD) in 560 older surgical patients (≥70 years), including a nested MRI cohort (n=146). We observed a discrepancy in the effect of delirium on cognitive decline as a function of MRI participation. Although overall difference in cognitive decline due to delirium was not greater than what might be expected due to chance (p=.21), in the non-MRI group delirium was associated with a faster pace of LTCD (−0.063, 95% CI −0.094 to −0.032, p<.001); while in the MRI group the effect of delirium was less and not significant (−0.023, 95% CI −0.076, 0.030, p=.39). Since this limits our ability to investigate the neural correlates of delirium and cognitive decline using MRI data, we attempted to mitigate the observed discrepancy using inverse probability weighting for MRI participation. The approach was not successful and the difference of the effect of delirium in slope was essentially unchanged. There was no evidence that the MRI sub-group experienced delirium that differed in severity relative to MRI non-participants. We could not attribute the observed discrepancy to selection bias based on measured factors. It may reflect a power issue due to the smaller MRI subsample or selection bias from unmeasured factors.
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影响因子：
4.8
作者：
Jaramillo, Sarah A.;Felton, Deborah;Espeland, Mark A.
通讯作者：
Espeland, Mark A.
影响因子：
6.3
作者：
Saczynski JS;Kosar CM;Xu G;Puelle MR;Schmitt E;Jones RN;Marcantonio ER;Wong B;Isaza I;Inouye SK
通讯作者：
Inouye SK
DOI：
10.1111/j.1532-5415.2005.53120.x
发表时间：
2005-02-01
影响因子：
6.3
作者：
Inouye, SK;Leo-Summers, L;Agostini, JV
通讯作者：
Agostini, JV
大手术后，社区级别的社会劣势和ir妄的风险。
影响因子：
6.3
作者：
Arias F;Chen F;Fong TG;Shiff H;Alegria M;Marcantonio ER;Gou Y;Jones RN;Travison TG;Schmitt EM;Kind AJH;Inouye SK
通讯作者：
Inouye SK
影响因子：
5.7
作者：
Gross AL;Jones RN;Fong TG;Tommet D;Inouye SK
通讯作者：
Inouye SK