Synapses with inhibitory neurons differentiate anterior cingulate from dorsolateral prefrontal pathways associated with cognitive control.
Synapses with inhibitory neurons differentiate anterior cingulate from dorsolateral prefrontal pathways associated with cognitive control.
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DOI：
10.1016/j.neuron.2009.01.006
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发表时间：
2009-02-26
期刊：
影响因子：
16.2
通讯作者：
Barbas, Helen
中科院分区：
文献类型：
--
作者：
Medalla, Maria;Barbas, Helen
灵长类动物背外侧前额叶皮质(DLPFC)和前扣带回皮质(ACC)在认知任务中集中注意相关信号并抑制噪声。然而，它们的突触相互作用和在认知控制中的独特作用尚不清楚。我们报告了两条通往DLPFC区9的不同通路，一条来自邻近的46区，另一条来自功能不同的ACC，类似地支配与选择相关刺激相关的兴奋性神经元。然而，ACC与抑制性神经元的突触较多，突触较大，并优先支配钙结合蛋白抑制神经元，通过抑制兴奋性神经元来减少噪声。相比之下，46区主要支配钙调蛋白抑制神经元，从而解除对兴奋性神经元的抑制。这些突触的特化表明，在涉及冲突、错误或颠倒决定的挑战性认知任务中，ACC在减少背外侧区的噪音方面有更大的影响，这些机制在精神分裂症中被破坏。这些观察结果突出了DLPFC和ACC在认知控制中的独特作用。
The primate dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are unknown. We report that two distinct pathways to DLPFC area 9, one from the neighboring area 46 and the other from the functionally distinct ACC, similarly innervate excitatory neurons associated with selecting relevant stimuli. However, ACC has more prevalent and larger synapses with inhibitory neurons and preferentially innervates calbindin inhibitory neurons, which reduce noise by inhibiting excitatory neurons. In contrast, area 46 mostly innervates calretinin inhibitory neurons, which disinhibit excitatory neurons. These synaptic specializations suggest that ACC has a greater impact in reducing noise in dorsolateral areas during challenging cognitive tasks involving conflict, error, or reversing decisions, mechanisms that are disrupted in schizophrenia. These observations highlight the unique roles of the DLPFC and ACC in cognitive control.
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