A polymorphism in human estrogen-related receptor beta (ESRRβ) predicts audiometric temporary threshold shift.
A polymorphism in human estrogen-related receptor beta (ESRRβ) predicts audiometric temporary threshold shift.
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DOI：
10.1080/14992027.2016.1192693
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发表时间：
2016-10
影响因子：
2.7
通讯作者：
Henrich V
中科院分区：
文献类型：
--
作者：
Bhatt I;Phillips S;Richter S;Tucker D;Lundgren K;Morehouse R;Henrich V
在我们之前的研究中，人类雌激素相关受体β (ESRRβ)配体结合域的非同义单核苷酸多态性（rs61742642; C to T, P386S）可能与噪声性听力损失（NIHL）有关。本研究旨在研究ESRRβ rs61742642 T变异对临时阈值移位（TTS）的影响。以2000Hz为中心的听力学窄带噪声暴露10min，诱发TTS。测量噪声暴露前后2000、3000和4000Hz的听力阈值和失真乘积耳声发射输入输出函数（DP IO）。该研究招募了19名rs61742642 CT基因型和40名rs61742642CC基因型的参与者。与CC基因型的参与者相比，CT基因型的参与者获得了显著更高的TTS，但没有令人信服的证据表明DP IO临时水平偏移（DPTLS）更大。结果表明，ESRRβ多态性与TTS相关。未来的研究建议探索导致NIHL易感性增加的分子途径。
A non-synonymous single nucleotide polymorphism (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta (ESRRβ) showed possible association to noise-induced hearing loss (NIHL) in our previous study. This study was conducted to examine the effect of the ESRRβ rs61742642 T variant on temporary threshold shift (TTS). TTS was induced by 10minutes of exposure to audiometric narrow-band noise centered at 2000Hz. Hearing thresholds and distortion product otoacoustic emissions input output function (DP IO) at 2000, 3000, and 4000Hz were measured before and after the noise exposure. Nineteen participants with rs61742642 CT genotype and 40 participants with rs61742642CC genotype were recruited for the study. Participants with the CT genotype acquired a significantly greater TTS without convincing evidence of greater DP IO temporary level shift (DPTLS) compared to participants with the CC genotype. The results indicated that the ESRRβ polymorphism is associated with TTS. Future studies were recommended to explore molecular pathways leading to increased susceptibility to NIHL.
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