Childhood sexual abuse and the development of recurrent major depression in Chinese women.
Childhood sexual abuse and the development of recurrent major depression in Chinese women.
复制标题
DOI：
10.1371/journal.pone.0087569
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Flint J
中科院分区：
文献类型：
--
作者：
Chen J;Cai Y;Cong E;Liu Y;Gao J;Li Y;Tao M;Zhang K;Wang X;Gao C;Yang L;Li K;Shi J;Wang G;Liu L;Zhang J;Du B;Jiang G;Shen J;Zhang Z;Liang W;Sun J;Hu J;Liu T;Wang X;Miao G;Meng H;Li Y;Hu C;Li Y;Huang G;Li G;Ha B;Deng H;Mei Q;Zhong H;Gao S;Sang H;Zhang Y;Fang X;Yu F;Yang D;Liu T;Chen Y;Hong X;Wu W;Chen G;Cai M;Song Y;Pan J;Dong J;Pan R;Zhang W;Shen Z;Liu Z;Gu D;Wang X;Liu X;Zhang Q;Li Y;Chen Y;Kendler KS;Shi S;Flint J
我们之前对中国汉族女性的研究表明，有童年性虐待史（CSA）的女性患重度抑郁症（MD）的风险增加。在我们的整个数据集中可以找到这种关系吗？通过自我报告对两组汉族女性的 CSA 三个水平（非生殖器、生殖器和性交）进行评估：6017 名临床确定的复发性 MD 和 5983 名匹配对照。在个人访谈中评估诊断和其他危险因素信息。通过逻辑回归计算优势比（OR）。我们通过对 3,950 个新的复发性 MD 病例重复先前的分析，证实了先前的结果。两个数据集之间没有显着差异。任何形式的 CSA 均与复发性 MD 显着相关（OR 4.06，95% 置信区间 (CI) [3.19–5.24]）。这种关联随着 CSA 严重程度的增加而加强：非生殖器（OR 2.21，95% CI 1.58–3.15）、生殖器（OR 5.24，95% CI 3.52–8.15）和性交（OR 10.65，95% CI 5.56–23.71）。在抑郁女性中，患有 CSA 的女性发病年龄较早，抑郁发作时间较长。患有 CSA 的复发性 MD 患者出现心境恶劣（OR 1.60，95%CI 1.11–2.27）和恐惧症（OR 1.41，95%CI 1.09–1.80）的风险增加。任何形式的CSA都与自杀意念或企图（OR 1.50，95% CI 1.20-1.89）以及无价值感或内疚感（OR 1.41，95% CI 1.02-2.02）显着相关。性交（OR 3.47，95%CI 1.66–8.22）、使用武力和威胁（OR 1.95，95%CI 1.05–3.82）以及受害者当时受到的影响程度（OR 1.39，95%CI 1.20–1.64）与MD复发显着相关。在中国女性中，CSA 与复发性 MD 密切相关，并且这种关联随着 CSA 严重程度的增加而增加。患有 CSA 的抑郁女性有一些特定的临床特征。 CSA 的某些特征与发生复发性 MD 的可能性更大有关。
Our prior study in Han Chinese women has shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found in our whole data set? Three levels of CSA (non-genital, genital, and intercourse) were assessed by self-report in two groups of Han Chinese women: 6017 clinically ascertained with recurrent MD and 5983 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression. We confirmed earlier results by replicating prior analyses in 3,950 new recurrent MD cases. There were no significant differences between the two data sets. Any form of CSA was significantly associated with recurrent MD (OR 4.06, 95% confidence interval (CI) [3.19–5.24]). This association strengthened with increasing CSA severity: non-genital (OR 2.21, 95% CI 1.58–3.15), genital (OR 5.24, 95% CI 3.52–8.15) and intercourse (OR 10.65, 95% CI 5.56–23.71). Among the depressed women, those with CSA had an earlier age of onset, longer depressive episodes. Recurrent MD patients those with CSA had an increased risk for dysthymia (OR 1.60, 95%CI 1.11–2.27) and phobia (OR 1.41, 95%CI 1.09–1.80). Any form of CSA was significantly associated with suicidal ideation or attempt (OR 1.50, 95% CI 1.20–1.89) and feelings of worthlessness or guilt (OR 1.41, 95% CI 1.02–2.02). Intercourse (OR 3.47, 95%CI 1.66–8.22), use of force and threats (OR 1.95, 95%CI 1.05–3.82) and how strongly the victims were affected at the time (OR 1.39, 95%CI 1.20–1.64) were significantly associated with recurrent MD. In Chinese women CSA is strongly associated with recurrent MD and this association increases with greater severity of CSA. Depressed women with CSA have some specific clinical traits. Some features of CSA were associated with greater likelihood of developing recurrent MD.
登录
查看更多内容
影响因子：
3.2
作者：
Bedi, Saaniya;Nelson, Elliot C.;Martin, Nicholas G.
通讯作者：
Martin, Nicholas G.
影响因子：
8.9
作者：
Chen, Laura P.;Murad, M. Hassan;Zirakzadeh, Ali
通讯作者：
Zirakzadeh, Ali
影响因子：
3.1
作者：
Andrews, B
通讯作者：
Andrews, B
影响因子：
10.5
作者：
Bulik, CM;Prescott, CA;Kendler, KS
通讯作者：
Kendler, KS
影响因子：
6.9
作者：
Cong, E.;Li, Y.;Shi, S.
通讯作者：
Shi, S.