Neural correlates of inhibitory deficits in depression.

Neural correlates of inhibitory deficits in depression.
复制标题

DOI:
10.1016/j.pscychresns.2009.07.010
复制
发表时间:
2010-01-30
影响因子:
2.3
通讯作者:
Gotlib, Ian H.
Gotlib, Ian H.
中科院分区:
医学4区
文献类型:
--
作者:
Eugene, Fanny;Joormann, Jutta;Cooney, Rebecca E.;Atlas, Lauren Y.;Gotlib, Ian H.

文献摘要

参考文献

被引文献

相似文献

本研究的目的是检查神经相关的抑制功能障碍的个人诊断为重度抑郁症(MDD)。12名MDD参与者和12名从未抑郁的对照者在扫描仪中完成了负性情感启动(NAP)任务。结果表明,在抑郁的参与者,在喙前扣带皮层(rACC)的激活增加与抑制消极的,但不是积极的,话;相反,在非抑郁的参与者,抑制积极的,但不是消极的,话与rACC的激活增加。这些发现表明,神经功能异常,特别是在rACC,可能是抑郁症患者在抑制消极思想方面遇到困难的基础。这些结果强调了继续研究抑郁症中认知和神经功能之间关系的重要性,以获得对这种疾病更广泛和更全面的理解。
The present study was designed to examine neural correlates of inhibitory dysfunction in individuals diagnosed with Major Depressive Disorder (MDD). Twelve MDD participants and 12 never-depressed controls completed the negative affective priming (NAP) task in the scanner. Results indicated that, in depressed participants, increased activation in the rostral anterior cingulate cortex (rACC) is associated with inhibition of negative, but not positive, words; in contrast, in nondepressed participants, inhibition of positive, but not negative, words is associated with increased activation in the rACC. These findings indicate that abnormalities in neural function, especially in the rACC, may underlie difficulties experienced by depressed individuals in inhibiting negative thoughts. These results underscore the importance of continuing to examine the relation between cognitive and neural functioning in depression in order to gain a broader and more integrative understanding of this disorder.
DOI: 10.1016/j.neulet.2008.01.011
发表时间: 2008-03-15
影响因子: 2.5
作者:
Leung, Kwok-Keung;Lee, Tatia M. C.;Li, Leonard S. W.
通讯作者: Li, Leonard S. W.
DOI: 10.1006/nimg.1997.0278
发表时间: 1997-08-01
期刊: NEUROIMAGE
影响因子: 5.7
作者:
Cohen, MS
通讯作者: Cohen, MS
DOI: 10.1007/s10608-006-9035-8
发表时间: 2006-04-01
影响因子: 2.8
作者:
Joormann, Jutta
通讯作者: Joormann, Jutta
DOI: 10.1097/00001756-199703030-00048
发表时间: 1997-03-03
期刊: NEUROREPORT
影响因子: 1.7
作者:
Mayberg, HS;Brannan, SK;Fox, PT
通讯作者: Fox, PT
DOI: 10.1176/appi.ajp.160.1.64
发表时间: 2003-01-01
影响因子: 17.7
作者:
Davidson, RJ;Irwin, W;Kalin, NH
通讯作者: Kalin, NH